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Literature summary for 1.15.1.1 extracted from

  • Rasheed, Z.; Alzolibani, A.A.; Al-Shobaili, H.A.; Saif, G.B.; Al Robaee, A.A.
    Biochemical and immunological studies on erythrocytes superoxide dismutase modified by nitric oxide in patients with alopecia areata implications in alopecia patchy persistent and alopecia universalis (2014), Immunol. Lett., 160, 50-57 .
    View publication on PubMed
Search for more literature for 1.15.1.1

Inhibitors

Inhibitors Comment Organism Structure
additional information NO-induced damage in eSOD causes alteration in hydrophobic or aromatic amino acids and protein carbonyl contents Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ a Cu/Zn-SOD Homo sapiens
Zn2+ a Cu/Zn-SOD Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 superoxide + 2 H+ Homo sapiens
-
 O2 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P00441
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 superoxide + 2 H+
-
 Homo sapiens O2 + H2O2
-
 ?
additional information the enzyme activity is detected by its ability to inhibit the autoxidation of epinephrine at pH 10.2 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
erythrocyte superoxide dismutase
-
 Homo sapiens
eSOD
-
 Homo sapiens
SOD
-
 Homo sapiens
SOD1
-
 Homo sapiens
superoxide dismutase [Cu-Zn] UniProt Homo sapiens

General Information

General Information Comment Organism
malfunction Role of nitric oxide (NO) modified erythrocytes superoxide dismutase (eSOD) in alopecia areata, a non-scarring hair loss disorder. dysfunctioning of SODis reported in patients with alopecia areata. Protein-A purified IgG of alopecia areata patients (AA-IgG) show strong binding to NO-eSOD in comparison with IgG from controls. In addition, AA-IgG from patients with alopecia universalis recognize NO-eSOD in a greater extentas compared to AA-IgG from patients with patchy persistent alopecia areata. Alopecia universalis patients' sera contain higher levels of NO or carbonyl contents and lower levels of SOD activity compared with patchy persistent alopecia areata patient or control sera Homo sapiens
additional information NO-induced damage in eSOD causes alteration in hydrophobic or aromatic amino acids and protein carbonyl contents Homo sapiens
physiological function superoxide dismutase (SOD) is a prime antioxidant enzymethat destroys the effects of superoxide, thus limiting the dele-terious effects of reactive oxygen and nitrogen species. SOD is considered an important regulator of oxida-tive/nitrosative stress Homo sapiens