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Literature summary for 1.15.1.1 extracted from

  • Rumfeldt, J.A.; Lepock, J.R.; Meiering, E.M.
    Unfolding and folding kinetics of amyotrophic lateral sclerosis-associated mutant Cu,Zn superoxide dismutases (2009), J. Mol. Biol., 385, 278-298.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
E100G an amyotrophic lateral sclerosis-associated naturally occuring SOD mutant, misfolding/aggregation mechanism with folding and unfolding kinetics, overview Homo sapiens
G85R an amyotrophic lateral sclerosis-associated naturally occuring SOD mutant, misfolding/aggregation mechanism with folding and unfolding kinetics, overview Homo sapiens
G93A an amyotrophic lateral sclerosis-associated naturally occuring SOD mutant, misfolding/aggregation mechanism with folding and unfolding kinetics, overview Homo sapiens
G93R an amyotrophic lateral sclerosis-associated naturally occuring SOD mutant, misfolding/aggregation mechanism with folding and unfolding kinetics, overview Homo sapiens
H46R an amyotrophic lateral sclerosis-associated naturally occuring SOD mutant, misfolding/aggregation mechanism with folding and unfolding kinetics, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Cu a Cu,Zn superoxide dismutase Homo sapiens
additional information the enzyme contains no iron Homo sapiens
Zn a Cu,Zn superoxide dismutase Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
dimeric wild-type holo-enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Renatured (Commentary)

Renatured (Comment) Organism
enzyme folding and unfolding kinetic mechanism of wild-type and mutant enzymes at pH 7.8 and 25°C, role of metal ions, overview Homo sapiens

Subunits

Subunits Comment Organism
dimer wild-type holo-enzyme Homo sapiens
monomer or dimer the kinetic mechanism for holo SODs involves native dimer-monomer intermediate, and unfolded monomer, with variable metal dissociation from the monomeric states depending on solution conditions, overview. Naturally occuring mutants seem to favour increased formation of a Zn-free monomer intermediate, which is implicated in the formation of toxic aggregates. Kinetic basis for the extremely high stability of wild-type holo SOD, overview Homo sapiens

Synonyms

Synonyms Comment Organism
Cu,Zn superoxide dismutase
-
Homo sapiens
SOD
-
Homo sapiens