Protein Variants | Comment | Organism |
---|---|---|
E100G | an amyotrophic lateral sclerosis-associated naturally occuring SOD mutant, misfolding/aggregation mechanism with folding and unfolding kinetics, overview | Homo sapiens |
G85R | an amyotrophic lateral sclerosis-associated naturally occuring SOD mutant, misfolding/aggregation mechanism with folding and unfolding kinetics, overview | Homo sapiens |
G93A | an amyotrophic lateral sclerosis-associated naturally occuring SOD mutant, misfolding/aggregation mechanism with folding and unfolding kinetics, overview | Homo sapiens |
G93R | an amyotrophic lateral sclerosis-associated naturally occuring SOD mutant, misfolding/aggregation mechanism with folding and unfolding kinetics, overview | Homo sapiens |
H46R | an amyotrophic lateral sclerosis-associated naturally occuring SOD mutant, misfolding/aggregation mechanism with folding and unfolding kinetics, overview | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu | a Cu,Zn superoxide dismutase | Homo sapiens | |
additional information | the enzyme contains no iron | Homo sapiens | |
Zn | a Cu,Zn superoxide dismutase | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
dimeric wild-type holo-enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Renatured (Comment) | Organism |
---|---|
enzyme folding and unfolding kinetic mechanism of wild-type and mutant enzymes at pH 7.8 and 25°C, role of metal ions, overview | Homo sapiens |
Subunits | Comment | Organism |
---|---|---|
dimer | wild-type holo-enzyme | Homo sapiens |
monomer or dimer | the kinetic mechanism for holo SODs involves native dimer-monomer intermediate, and unfolded monomer, with variable metal dissociation from the monomeric states depending on solution conditions, overview. Naturally occuring mutants seem to favour increased formation of a Zn-free monomer intermediate, which is implicated in the formation of toxic aggregates. Kinetic basis for the extremely high stability of wild-type holo SOD, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Cu,Zn superoxide dismutase | - |
Homo sapiens |
SOD | - |
Homo sapiens |