Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 O2.- + 2 H+ | Allium sativum | - |
O2 + H2O2 | - |
? | |
additional information | Allium sativum | the enzyme is involved in activation and modulation of phospho-extracellular signal-regulated kinases proteins and in the control of several biological processes including cell proliferation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Allium sativum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme from bulbs by ammonium sulfate fractionation, dialysis, gel filtration, and anion exchange chromatography | Allium sativum |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bulb | - |
Allium sativum | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
89 | - |
purified enzyme | Allium sativum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 O2.- + 2 H+ | - |
Allium sativum | O2 + H2O2 | - |
? | |
2 O2.- + 2 H+ | activity determination by the epinephrine assay: at alkaline pH, superoxide anion O2- causes the oxidation of epinephrine to adrenochrome, SOD competes with this reaction by decreasing the adrenochrome formation | Allium sativum | O2 + H2O2 | - |
? | |
additional information | the enzyme is involved in activation and modulation of phospho-extracellular signal-regulated kinases proteins and in the control of several biological processes including cell proliferation | Allium sativum | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
manganese superoxide dismutase | - |
Allium sativum |
MnSOD | - |
Allium sativum |
SOD | - |
Allium sativum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Allium sativum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
10.2 | - |
assay at | Allium sativum |
General Information | Comment | Organism |
---|---|---|
physiological function | the exogenous manganese superoxide dismutase is able to modify the intracellular level of reactive oxygen species by eliminating superoxide anion and producing hydrogen peroxide. The cell viability of the two tumoral cell lines, porcine aortic endothelial cells and B16F0 mouse melanoma cells, exposed to the enzyme, is not significantly affected but the cell multiplication is arrested. The enzyme is involved in the control of several biological processes including cell proliferation | Allium sativum |