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Literature summary for 1.15.1.1 extracted from

  • Suzuki, J.; Broeyer, F.; Cohen, A.; Takebe, M.; Burggraaf, J.; Mizushima, Y.
    Pharmacokinetics of PC-SOD, a lecithinized recombinant superoxide dismutase, after single- and multiple-dose administration to healthy Japanese and Caucasian volunteers (2008), J. Clin. Pharmacol., 48, 184-192.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of human SOD in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information the recombinant SOD is cvalently linked to lecithin, which increases its half-life after administration to humans Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens pharmacokinetics of single and multiple doses of recombinant human superoxide dismutase covalently linked to lecithin in healthy Japanese and Caucasian volunteers are nonlinear with dose, showing a relatively long half-life of PC-SOD of over 24 hours, overview ?
-
?
O2.- + H+ Homo sapiens
-
O2 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
healthy Japanese and Caucasian individuals
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information measurement of serum and urinary PC-SOD concentrations after application of exogenous recombinant human isozyme to male and female humans, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information pharmacokinetics of single and multiple doses of recombinant human superoxide dismutase covalently linked to lecithin in healthy Japanese and Caucasian volunteers are nonlinear with dose, showing a relatively long half-life of PC-SOD of over 24 hours, overview Homo sapiens ?
-
?
O2.- + H+
-
Homo sapiens O2 + H2O2
-
?

Synonyms

Synonyms Comment Organism
SOD
-
Homo sapiens