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Literature summary for 1.15.1.1 extracted from

  • Kim, S.M.; Eum, W.S.; Kang, J.H.
    Expression, purification, and characterization of a familial amyotrophic lateral sclerosis-associated D90A Cu,Zn-superoxide dismutase mutant (1998), Mol. Cells, 8, 478-482.
    View publication on PubMed
Search for more literature for 1.15.1.1

Cloned(Commentary)

Cloned (Comment) Organism
Cu,Zn-SOD, expression of wild-type and mutant in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
D90A Cu,Zn-SOD, mutant found in familial amyotrophic lateral sclerosis, activity similar compared to native and recombinant wild-type, but enhanced OH- generating activity, mutant is more sensitive to inhibition by copper-chelators Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
diethyldithiocarbamate copper-chelator, wild-type and mutant Cu,Zn-SOD Homo sapiens
Penicillamine copper-chelator, wild-type and mutant Cu,Zn-SOD Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+
-
 Homo sapiens
Zn2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 Cu,Zn-SOD
-
Homo sapiens CuZn-SOD
-
 Cu,Zn-SOD
-

Purification (Commentary)

Purification (Comment) Organism
Cu,Zn-SOD wild-type and mutant recombinant from Escherichia coli Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O2- + H+
-
 Homo sapiens O2 + H2O2
-
 r
O2- + H+
-
 Homo sapiens CuZn-SOD O2 + H2O2
-
 r

Subunits

Subunits Comment Organism
? x * 15764-15809, Cu,Zn-SOD wild-type and mutant D90A, electrospray mass spectroscopy Homo sapiens