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Literature summary for 1.14.99.66 extracted from

  • Lloret-Llinares, M.; Carre, C.; Vaquero, A.; de Olano, N.; Azorin, F.
    Characterization of Drosophila melanogaster JmjC+N histone demethylases (2008), Nucleic Acids Res., 36, 2852-2863 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.99.66

Cloned(Commentary)

Cloned (Comment) Organism
gene lid, sequence comparisons, transient recombinant overexpression of FLAG-tagged enzyme in S2 cells Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
additional information overexpression of dJARID1/Lid results in a strong reduction in the overall levels of H3K4me3. A strong increase in H3K4me3 is also detected in polytene chromosomes from homozygous lid12367 mutants. Gene lid mutations resulting in small imaginal discs. In homozygous lid12367 larvae, the pattern of Ubx expression is not altered but expression in haltere discs is reduced being similar to that observed in leg discs, which is in contrast with the much higher expression in haltere versus leg discs observed in wild-type larvae Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Drosophila melanogaster 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 acceptor + 2 H2O Drosophila melanogaster overall reaction [histone H3]-L-lysine4 + 2 formaldehyde + 2 reduced acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9VMJ7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
larva
-
 Drosophila melanogaster
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salivary gland
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 acceptor + 2 H2O overall reaction Drosophila melanogaster [histone H3]-L-lysine4 + 2 formaldehyde + 2 reduced acceptor
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 ?

Synonyms

Synonyms Comment Organism
dJARID1/Lid
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 Drosophila melanogaster
Jarid1
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 Drosophila melanogaster
LD40310
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 Drosophila melanogaster
Lid
-
 Drosophila melanogaster

General Information

General Information Comment Organism
evolution the enzyme belongs to the JARID family. JARID proteins contain, in addition to the JmjN and JmjC domains, ARID and C5HC2-zinc finger domains, which mediate DNA binding. JARID proteins are, in turn, divided into two subgroups according to the presence, JARID1, or not, JARID2, of chromatin-binding PHD domains Drosophila melanogaster
malfunction a strong increase in H3K4me3 is detected in polytene chromosomes from homozygous lid12367 mutants. Gene lid mutations result in small imaginal discs Drosophila melanogaster
physiological function overexpression of dJARID1/Lid results in a strong reduction in the overall levels of H3K4me3, on the other hand, no significant effects on the levels of H3K9me3, H3K27me3 and H3K36me3 are detected. Independent of its demethylase activity, lid regulates cell proliferation through its interaction with myc Drosophila melanogaster