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Literature summary for 1.14.99.65 extracted from

  • Makris, T.M.; Chakrabarti, M.; Muenck, E.; Lipscomb, J.D.
    A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis (2010), Proc. Natl. Acad. Sci. USA, 107, 15391-15396 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.99.65

Organism

Organism UniProt Comment Textmining
Streptomyces venezuelae F2RB80
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Streptomyces venezuelae DSM 40230 F2RB80
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] + reduced acceptor + O2
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 Streptomyces venezuelae 2-(4-aminophenyl)-L-seryl-[CmlP-peptidyl-carrier-protein] + acceptor + H2O
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 ?
4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] + reduced acceptor + O2
-
 Streptomyces venezuelae DSM 40230 2-(4-aminophenyl)-L-seryl-[CmlP-peptidyl-carrier-protein] + acceptor + H2O
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 ?
additional information CmlA contains an oxo-bridged dinuclear iron cluster. CmlA is functional in the diferrous state, and substrate L-PAPA is covalently bound to CmlP. The product is hydroxylated L-PAPA and O2 is the oxygen source Streptomyces venezuelae ?
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 ?
additional information CmlA contains an oxo-bridged dinuclear iron cluster. CmlA is functional in the diferrous state, and substrate L-PAPA is covalently bound to CmlP. The product is hydroxylated L-PAPA and O2 is the oxygen source Streptomyces venezuelae DSM 40230 ?
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 ?