BRENDA - Enzyme Database show
show all sequences of 1.14.99.54

Lytic polysaccharide monooxygenases from Myceliophthora thermophila C1 differ in substrate preference and reducing agent specificity

Frommhagen, M.; Koetsier, M.J.; Westphal, A.H.; Visser, J.; Hinz, S.W.; Vincken, J.P.; van Berkel, W.J.; Kabel, M.A.; Gruppen, H.; Biotechnol. Biofuels 9, 186 (2016)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
;
Thermothelomyces heterothallicus
Crystallization (Commentary)
Crystallization
Organism
comparison of isoforms LPMO9A, LPMO9B and LPMO9C. LPMO9B contains distal from the coordinated copper sphere an additional loop (Gly115-Asn121), which is not present in LPMO9A and LPMO9C. The copper ion in LPMO9A, LPMO9B and LPMO9C is coordinated by His1-His68-Tyr153, His1-His79-Tyr170 and His1-His84-Tyr166, respectively. All three LPMOs share two putative disulfide bridges; comparison of isoforms LPMO9A, LPMO9B and LPMO9C. LPMO9B contains distal from the coordinated copper sphere an additional loop (Gly115-Asn121), which is not present in LPMO9A and LPMO9C. The copper ion in LPMO9A, LPMO9B and LPMO9C is coordinated by His1-His68-Tyr153, His1-His79-Tyr170 and His1-His84-Tyr166, respectively. All three LPMOs share two putative disulfide bridges
Thermothelomyces heterothallicus
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Cu2+
;
Thermothelomyces heterothallicus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Thermothelomyces heterothallicus
A0A0H4K9X4
-
-
Thermothelomyces heterothallicus
A0A1C9CXI1
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
beta-(1->3,1->4)-glucan + acceptor + O2
-
740210
Thermothelomyces heterothallicus
C1/C4-oxidized oxidized glucan oligosaccharides + reduced acceptor + H2O
-
-
-
?
cellulose + ascorbate + O2
substrate is regenerated amorphous cellulose
740210
Thermothelomyces heterothallicus
C1-oxidized glucooligosaccharides + glucooligosaccharides + dehydroascorbate + H2O
release of C1-oxidized and non-oxidized glucooligosaccharides
-
-
?
cellulose + ascorbate + O2
-
740210
Thermothelomyces heterothallicus
C1/C4-oxidized cello-oligosaccharides + dehydroascorbate + H2O
-
-
-
?
cellulose + oxidized dopamine + O2
-
740210
Thermothelomyces heterothallicus
C1-oxidized gluco-oligosaccharides + glucooligosaccharides + dopamine + H2O
dopamine shows 46% of the activity with ascorbate
-
-
?
additional information
for isoforms LPMO9A, LPMO9B and LPMO9C, ascorbic acid is one of the best electron donors. Besides ascorbic acid, compounds bearing a 1,2-benzenediol moiety such as 3-methylcatechol, 3,4-dihydroxyphenylalanine, or a 1,2,3-benzenetriol moiety such as gallic acid, epigallocatechin-gallate give the highest formation of oxidized and non-oxidized gluco-oligosaccharides. Sinapic acid actes as donor. No electron donor: quercetin or taxifolin, and tannic acid
740210
Thermothelomyces heterothallicus
?
-
-
-
-
additional information
no substrate: beta-(1->3, 1->4)-glucan. For isoforms LPMO9A, LPMO9B and LPMO9C, ascorbic acid is one of the best electron donors. Besides ascorbic acid, compounds bearing a 1,2-benzenediol moiety such as 3-methylcatechol, 3,4-dihydroxyphenylalanine, or a 1,2,3-benzenetriol moiety such as gallic acid, epigallocatechin-gallate give the highest formation of oxidized and non-oxidized gluco-oligosaccharides. Sinapic acid actes as donor. No electron donor: quercetin or taxifolin, and tannic acid
740210
Thermothelomyces heterothallicus
?
-
-
-
-
xylan + dopamine + O2
-
740210
Thermothelomyces heterothallicus
C1/C4-oxidized oxidized xylo-oligosaccharides + 4-(2-aminoethyl)cyclohexa-3,5-diene-1,2-dione + H2O
93% of the activiy with ascorbate
-
-
?
xyloglucan + acceptor + O2
-
740210
Thermothelomyces heterothallicus
C1/C4-oxidized oxidized oligosaccharides + reduced acceptor + H2O
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 30633, calculated
Thermothelomyces heterothallicus
Cloned(Commentary) (protein specific)
Commentary
Organism
-
Thermothelomyces heterothallicus
Crystallization (Commentary) (protein specific)
Crystallization
Organism
comparison of isoforms LPMO9A, LPMO9B and LPMO9C. LPMO9B contains distal from the coordinated copper sphere an additional loop (Gly115-Asn121), which is not present in LPMO9A and LPMO9C. The copper ion in LPMO9A, LPMO9B and LPMO9C is coordinated by His1-His68-Tyr153, His1-His79-Tyr170 and His1-His84-Tyr166, respectively. All three LPMOs share two putative disulfide bridges
Thermothelomyces heterothallicus
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Cu2+
-
Thermothelomyces heterothallicus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
beta-(1->3,1->4)-glucan + acceptor + O2
-
740210
Thermothelomyces heterothallicus
C1/C4-oxidized oxidized glucan oligosaccharides + reduced acceptor + H2O
-
-
-
?
cellulose + ascorbate + O2
substrate is regenerated amorphous cellulose
740210
Thermothelomyces heterothallicus
C1-oxidized glucooligosaccharides + glucooligosaccharides + dehydroascorbate + H2O
release of C1-oxidized and non-oxidized glucooligosaccharides
-
-
?
cellulose + ascorbate + O2
-
740210
Thermothelomyces heterothallicus
C1/C4-oxidized cello-oligosaccharides + dehydroascorbate + H2O
-
-
-
?
cellulose + oxidized dopamine + O2
-
740210
Thermothelomyces heterothallicus
C1-oxidized gluco-oligosaccharides + glucooligosaccharides + dopamine + H2O
dopamine shows 46% of the activity with ascorbate
-
-
?
additional information
for isoforms LPMO9A, LPMO9B and LPMO9C, ascorbic acid is one of the best electron donors. Besides ascorbic acid, compounds bearing a 1,2-benzenediol moiety such as 3-methylcatechol, 3,4-dihydroxyphenylalanine, or a 1,2,3-benzenetriol moiety such as gallic acid, epigallocatechin-gallate give the highest formation of oxidized and non-oxidized gluco-oligosaccharides. Sinapic acid actes as donor. No electron donor: quercetin or taxifolin, and tannic acid
740210
Thermothelomyces heterothallicus
?
-
-
-
-
additional information
no substrate: beta-(1->3, 1->4)-glucan. For isoforms LPMO9A, LPMO9B and LPMO9C, ascorbic acid is one of the best electron donors. Besides ascorbic acid, compounds bearing a 1,2-benzenediol moiety such as 3-methylcatechol, 3,4-dihydroxyphenylalanine, or a 1,2,3-benzenetriol moiety such as gallic acid, epigallocatechin-gallate give the highest formation of oxidized and non-oxidized gluco-oligosaccharides. Sinapic acid actes as donor. No electron donor: quercetin or taxifolin, and tannic acid
740210
Thermothelomyces heterothallicus
?
-
-
-
-
xylan + dopamine + O2
-
740210
Thermothelomyces heterothallicus
C1/C4-oxidized oxidized xylo-oligosaccharides + 4-(2-aminoethyl)cyclohexa-3,5-diene-1,2-dione + H2O
93% of the activiy with ascorbate
-
-
?
xyloglucan + acceptor + O2
-
740210
Thermothelomyces heterothallicus
C1/C4-oxidized oxidized oligosaccharides + reduced acceptor + H2O
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 30633, calculated
Thermothelomyces heterothallicus
Other publictions for EC 1.14.99.54
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744131
Frommhagen
Quantification of the catalyt ...
Thermothelomyces heterothallicus
Appl. Microbiol. Biotechnol.
102
1281-1295
2018
-
1
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2
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1
1
1
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4
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6
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2
1
1
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-
744555
Song
Real-time imaging reveals tha ...
Trichoderma reesei
Biotechnol. Biofuels
11
41
2018
-
1
-
-
-
-
-
-
-
-
-
-
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1
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-
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1
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1
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1
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744556
Breslmayr
A fast and sensitive activity ...
Neurospora crassa
Biotechnol. Biofuels
11
79
2018
-
1
-
-
-
-
-
-
-
-
-
-
-
1
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1
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1
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1
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-
-
-
-
744804
Sanhueza
The effect of a lytic polysac ...
Gloeophyllum trabeum, Gloeophyllum trabeum 925-B
Enzyme Microb. Technol.
113
75-82
2018
-
1
1
-
-
-
-
-
-
-
-
-
-
5
-
1
-
-
-
-
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2
1
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1
1
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2
1
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745380
Forsberg
Structural determinants of ba ...
Micromonospora aurantiaca, Micromonospora aurantiaca DSM 43813, Streptomyces coelicolor, Streptomyces coelicolor ATCC BAA-471
J. Biol. Chem.
293
1397-1412
2018
-
-
2
2
12
-
-
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2
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5
-
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8
-
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2
12
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8
-
-
-
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-
-
-
-
-
745381
Kracher
Active-site copper reduction ...
Neurospora crassa
J. Biol. Chem.
293
1676-1687
2018
-
-
1
-
-
-
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1
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2
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5
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2
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5
-
-
-
-
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-
1
1
-
-
-
745847
Couturier
Lytic xylan oxidases from woo ...
Trametes coccinea
Nat. Chem. Biol.
14
306-310
2018
-
1
1
1
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-
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1
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2
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3
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2
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1
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3
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746487
Hu
Enzyme mediated nanofibrillat ...
Thermoascus aurantiacus
Sci. Rep.
8
3195
2018
-
1
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1
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1
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739799
Frandsen
Learning from oligosaccharide ...
Aspergillus oryzae, Aspergillus oryzae ATCC 42149
Acta Crystallogr. Sect. D
73
64-76
2017
-
-
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1
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1
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4
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2
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739826
O'Dell
Crystallization of a fungal ly ...
Neurospora crassa, Neurospora crassa DSM 1257
Acta Crystallogr. Sect. F
73
70-78
2017
-
-
1
1
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9
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1
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739859
ODell
Oxygen activation at the activ ...
Neurospora crassa, Neurospora crassa DSM 1257
Angew. Chem. Int. Ed. Engl.
56
767-770
2017
-
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1
1
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1
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6
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740264
Frandsen
Unliganded and substrate bound ...
Lentinus similis
Carbohydr. Res.
448
187-190
2017
-
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1
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740400
Pierce
Oxidative cleavage and hydroly ...
Trichoderma reesei
Enzyme Microb. Technol.
98
58-66
2017
-
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1
1
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741358
Tanghe
Disulfide bridges as essential ...
Streptomyces coelicolor, Streptomyces coelicolor ATCC BAA-471
Protein Eng. Des. Sel.
30
401-408
2017
-
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3
-
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5
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1
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743929
Hedegard
-
Multiscale modelling of lytic ...
Thermoascus aurantiacus
ACS Omega
2
536-545
2017
-
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1
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744472
Courtade
Chemical shift assignments fo ...
Streptomyces coelicolor, Streptomyces coelicolor ATCC BAA-471
Biomol. NMR Assign.
11
257-264
2017
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1
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1
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6
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744627
Rodrigues
Recombinant expression of The ...
Thermobifida fusca, Thermobifida fusca E7
Carbohydr. Res.
448
175-181
2017
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1
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4
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1
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744628
Moellers
On the formation and role of ...
Thermoascus aurantiacus, Thielavia terrestris
Carbohydr. Res.
448
182-186
2017
2
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2
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744630
Valenzuela
Fast purification method of f ...
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Carbohydr. Res.
448
205-211
2017
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3
1
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744631
Courtade
A novel expression system for ...
Bacillus licheniformis, Cellvibrio japonicus
Carbohydr. Res.
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2017
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744632
Pierce
A comparative study on the ac ...
Aspergillus terreus, Trichoderma reesei
Carbohydr. Res.
449
85-94
2017
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2
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2
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5
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744633
Gusakov
Monitoring of reactions catal ...
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452
156-161
2017
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3
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3
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3
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744639
Haske-Cornelius
-
Enzymatic systems for cellulo ...
Neurospora crassa
Catalysts
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2017
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1
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744815
Pierce
Oxidative cleavage and hydrol ...
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2017
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3
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745374
Hansson
High-resolution structure of ...
Trichoderma reesei, Trichoderma reesei QM6a
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292
19099-19109
2017
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1
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2
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Hedegard
Targeting the reactive interm ...
Lentinus similis
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745861
Simmons
Structural and electronic det ...
Collariella virescens, Lentinus similis
Nat. Commun.
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1064
2017
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1
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1
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5
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745866
Eibinger
Single-molecule study of oxid ...
Neurospora crassa
Nat. Commun.
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894
2017
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1
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746230
Liu
Biochemical studies of two ly ...
Heterobasidion irregulare
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1
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746362
Tanghe
Disulfide bridges as essentia ...
Streptomyces coelicolor, Streptomyces coelicolor ATCC BAA-471
Protein Eng. Des. Sel.
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2017
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735822
Patel
Salt-responsive lytic polysacc ...
Pestalotiopsis sp. NCi6
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740210
Frommhagen
Lytic polysaccharide monooxyge ...
Thermothelomyces heterothallicus
Biotechnol. Biofuels
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744907
Nekiunaite
FgLPMO9A from Fusarium gramin ...
Fusarium graminearum, Fusarium graminearum ATCC MYA-4620
FEBS Lett.
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3346-3356
2016
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735814
Frommhagen
Discovery of the combined oxid ...
Thermothelomyces thermophilus, Thermothelomyces thermophilus C1
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Structural and functional char ...
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2015
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740207
Frommhagen
Discovery of the combined oxid ...
Thermothelomyces heterothallicus
Biotechnol. Biofuels
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1
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740287
Selig
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Modified cellobiohydrolase-cel ...
Streptomyces coelicolor, Streptomyces coelicolor ATCC BAA-471
Cellulose
22
2263-2270
2015
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740896
Vermaas
Effects of lytic polysaccharid ...
Trichoderma reesei, Trichoderma reesei QM6a
J. Phys. Chem. B
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6129-6143
2015
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Arfi
Integration of bacterial lytic ...
Thermobifida fusca
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2014
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2
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740205
Book
Evolution of substrate specifi ...
Neurospora crassa, Neurospora crassa DSM 1257, Serratia marcescens, Thermoascus aurantiacus, Thielavia terrestris, Trichoderma reesei, Trichoderma reesei QM6a, Vibrio cholerae O1, Vibrio cholerae O1 ATCC 39315
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109
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Eibinger
Cellulose surface degradation ...
Neurospora crassa, Neurospora crassa DSM 1257
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289
35929-35938
2014
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4
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741334
Kim
Quantum mechanical calculation ...
Thermoascus aurantiacus
Proc. Natl. Acad. Sci. USA
111
149-154
2014
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741336
Forsberg
Structural and functional char ...
Streptomyces coelicolor, Streptomyces coelicolor ATCC BAA-471
Proc. Natl. Acad. Sci. USA
111
8446-8451
2014
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Bey
Cello-oligosaccharide oxidatio ...
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488-496
2013
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Wu
Crystal structure and computat ...
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2013
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741445
Li
Structural basis for substrate ...
Neurospora crassa, Neurospora crassa DSM 1257
Structure
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2012
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Phillips
Cellobiose dehydrogenase and a ...
Neurospora crassa, Neurospora crassa ATCC 24698
ACS Chem. Biol.
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1399-1406
2011
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12
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3
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12
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1
3
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