BRENDA - Enzyme Database show
show all sequences of 1.14.99.52

Shedding light on ovothiol biosynthesis in marine metazoans

Castellano, I.; Migliaccio, O.; D'Aniello, S.; Merlino, A.; Napolitano, A.; Palumbo, A.; Sci. Rep. 6, 21506 (2016)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene ovoA, multi-exonic gene with 18 exons, DNA and amino acid sequence analysis, sequence comparisons and phylogenetic analysis
Strongylocentrotus purpuratus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-histidine + L-cysteine + O2
Strongylocentrotus purpuratus
-
S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Strongylocentrotus purpuratus
W4XJA6
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
egg
sea urchin Strongylocentrotus purpuratus eggs contain high concentrations (in the mM range) of ovothiol C
Strongylocentrotus purpuratus
-
embryo
-
Strongylocentrotus purpuratus
-
additional information
enzyme expression analysis
Strongylocentrotus purpuratus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-histidine + L-cysteine + O2
-
746446
Strongylocentrotus purpuratus
S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
gene ovoA, multi-exonic gene with 18 exons, DNA and amino acid sequence analysis, sequence comparisons and phylogenetic analysis
Strongylocentrotus purpuratus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-histidine + L-cysteine + O2
Strongylocentrotus purpuratus
-
S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
egg
sea urchin Strongylocentrotus purpuratus eggs contain high concentrations (in the mM range) of ovothiol C
Strongylocentrotus purpuratus
-
embryo
-
Strongylocentrotus purpuratus
-
additional information
enzyme expression analysis
Strongylocentrotus purpuratus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-histidine + L-cysteine + O2
-
746446
Strongylocentrotus purpuratus
S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O
-
-
-
?
Expression
Organism
Commentary
Expression
Strongylocentrotus purpuratus
SpOvoA upstream region analysis reveals several metal and stress responsive elements, overview
up
General Information
General Information
Commentary
Organism
evolution
OvoA evolved in most marine metazoans and was lost in bony vertebrates during the transition from the aquatic to terrestrial environment. Evolutionary history of OvoA in metazoans, overview
Strongylocentrotus purpuratus
metabolism
gene ovoA is involved in ovothiol biosynthesis
Strongylocentrotus purpuratus
General Information (protein specific)
General Information
Commentary
Organism
evolution
OvoA evolved in most marine metazoans and was lost in bony vertebrates during the transition from the aquatic to terrestrial environment. Evolutionary history of OvoA in metazoans, overview
Strongylocentrotus purpuratus
metabolism
gene ovoA is involved in ovothiol biosynthesis
Strongylocentrotus purpuratus
Expression (protein specific)
Organism
Commentary
Expression
Strongylocentrotus purpuratus
SpOvoA upstream region analysis reveals several metal and stress responsive elements, overview
up
Other publictions for EC 1.14.99.52
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744709
Liao
Convergent evolution of ergot ...
Erwinia tasmaniensis, Microcystis aeruginosa, Moorea producens, Moorea producens PAL-8-15-08-1
ChemBioChem
18
2115-2118
2017
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12
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7
10
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-
745390
Peck
Go it alone four-electron oxi ...
Erwinia tasmaniensis
J. Biol. Inorg. Chem.
22
381-394
2017
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1
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1
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1
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2
2
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746445
Castellano
Shedding light on ovothiol bi ...
Paracentrotus lividus
Sci. Rep.
6
21056
2016
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1
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1
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1
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6
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3
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1
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-
-
-
2
4
4
2
-
-
746446
Castellano
Shedding light on ovothiol bi ...
Strongylocentrotus purpuratus
Sci. Rep.
6
21506
2016
-
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1
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1
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6
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3
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1
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1
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1
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3
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1
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1
2
2
1
-
-
734828
Song
Cysteine oxidation reactions c ...
Erwinia tasmaniensis, Erwinia tasmaniensis DSM 17950
Org. Lett.
16
2122-2125
2014
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1
1
-
1
-
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1
-
2
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6
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10
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1
1
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1
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1
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2
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10
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3
3
-
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-
743388
Hu
Bioinformatic and biochemical ...
Erwinia tasmaniensis
Org. Lett.
16
5382-5385
2014
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1
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1
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2
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1
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3
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3
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2
2
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745960
Song
Cysteine oxidation reactions ...
Erwinia tasmaniensis
Org. Lett.
16
2122-2125
2014
-
-
-
-
1
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-
-
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1
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3
-
1
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4
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1
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3
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4
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-
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2
2
-
-
-
733647
Mashabela
Substrate specificity of an ox ...
Erwinia tasmaniensis, Erwinia tasmaniensis DSM 17950
Chem. Commun. (Camb. )
49
7714-7716
2013
2
-
-
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5
1
1
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2
-
6
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1
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12
-
1
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5
1
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2
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5
1
1
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2
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12
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1
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5
1
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2
2
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6
6
734827
Song
Regioselectivity of the oxidat ...
Erwinia tasmaniensis, Erwinia tasmaniensis DSM 17950
Org. Lett.
15
4854-4857
2013
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1
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1
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6
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6
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1
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8
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1
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8
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3
3
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733972
Bushnell
Model iron-oxo species and the ...
Erwinia tasmaniensis, Erwinia tasmaniensis DSM 17950
Inorg. Chem.
51
13351-13356
2012
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1
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1
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2
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6
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4
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734024
Braunshausen
Identification and characteriz ...
Erwinia tasmaniensis, Erwinia tasmaniensis DSM 17950, Trypanosoma cruzi
J. Am. Chem. Soc.
133
1757-1759
2011
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2
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3
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2
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7
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2
2
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6
6
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