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Literature summary for 1.14.99.48 extracted from

  • Streit, B.R.; Kant, R.; Tokmina-Lukaszewska, M.; Celis, A.I.; Machovina, M.M.; Skaar, E.P.; Bothner, B.; DuBois, J.L.
    Time-resolved studies of IsdG protein identify molecular signposts along the non-canonical heme oxygenase pathway (2016), J. Biol. Chem., 291, 862-871.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus Q7A649
-
-
Staphylococcus aureus N315 Q7A649
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information an apparent meso-hydroxyheme is a likely common intermediate with the canonical heme oxygenases. Unlike heme oxygenases, this intermediate does not form with added H2O2 nor does it convert to verdoheme and CO. Rather, the next intermediates are a set of formyloxobilin isomers. These convert in separate fast and slow phases to beta-/delta-staphylobilin isomers and formaldehyde Staphylococcus aureus ?
-
?
additional information an apparent meso-hydroxyheme is a likely common intermediate with the canonical heme oxygenases. Unlike heme oxygenases, this intermediate does not form with added H2O2 nor does it convert to verdoheme and CO. Rather, the next intermediates are a set of formyloxobilin isomers. These convert in separate fast and slow phases to beta-/delta-staphylobilin isomers and formaldehyde Staphylococcus aureus N315 ?
-
?
protoheme + 5 reduced acceptor + 4 O2
-
Staphylococcus aureus 15-oxo-beta-bilirubin + Fe2+ + formaldehyde + 5 acceptor + 4 H2O
-
?
protoheme + 5 reduced acceptor + 4 O2
-
Staphylococcus aureus N315 15-oxo-beta-bilirubin + Fe2+ + formaldehyde + 5 acceptor + 4 H2O
-
?
protoheme + 5 reduced acceptor + 4 O2
-
Staphylococcus aureus 5-oxo-delta-bilirubin + Fe2+ + formaldehyde + 5 acceptor + 4 H2O
-
?
protoheme + 5 reduced acceptor + 4 O2
-
Staphylococcus aureus N315 5-oxo-delta-bilirubin + Fe2+ + formaldehyde + 5 acceptor + 4 H2O
-
?

Synonyms

Synonyms Comment Organism
isdG
-
Staphylococcus aureus