Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Staphylococcus aureus | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | A6QG37 | - |
- |
Staphylococcus aureus Newman | A6QG37 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
isdG | - |
Staphylococcus aureus |
General Information | Comment | Organism |
---|---|---|
metabolism | in the absence of heme, isoform IsdG is targeted for degradation by internally coded sequences. A flexible loop near the heme-binding pocket is required for IsdG degradation in the absence of heme. IsdG stability is increased by inhibiting ATPases | Staphylococcus aureus |
physiological function | in the vertebrate host, Staphylococcus aureus fulfills its iron requirement by obtaining heme-iron from host hemoproteins via IsdG- and IsdI-mediated heme degradation. Isoforms IsdG and IsdI are structurally and mechanistically analogous but are differentially regulated by iron and heme availability | Staphylococcus aureus |