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show all sequences of 1.14.99.48

IruO is a reductase for heme degradation by IsdI and IsdG proteins in Staphylococcus aureus

Loutet, S.A.; Kobylarz, M.J.; Chau, C.H.; Murphy, M.E.; J. Biol. Chem. 288, 25749-25759 (2013)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
protoheme + 4 AH2 + 4 O2
Staphylococcus aureus
-
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
?
protoheme + 4 AH2 + 4 O2
Staphylococcus aureus
-
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
?
protoheme + 4 AH2 + 4 O2
Staphylococcus aureus
-
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
?
protoheme + 4 AH2 + 4 O2
Staphylococcus aureus
-
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
?
protoheme + 4 AH2 + 4 O2
Staphylococcus aureus N315
-
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
?
protoheme + 4 AH2 + 4 O2
Staphylococcus aureus N315
-
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
?
protoheme + 4 AH2 + 4 O2
Staphylococcus aureus N315
-
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
?
protoheme + 4 AH2 + 4 O2
Staphylococcus aureus N315
-
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Staphylococcus aureus
Q7A649
isoform IsdG
-
Staphylococcus aureus
Q7A827
isoform IsdI
-
Staphylococcus aureus N315
Q7A649
isoform IsdG
-
Staphylococcus aureus N315
Q7A827
isoform IsdI
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
in the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus N315
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus N315
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
in the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus N315
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
in the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus N315
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus N315
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
in the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus N315
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
protoheme + 4 AH2 + 4 O2
Staphylococcus aureus
-
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
?
protoheme + 4 AH2 + 4 O2
Staphylococcus aureus
-
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
?
protoheme + 4 AH2 + 4 O2
Staphylococcus aureus
-
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
?
protoheme + 4 AH2 + 4 O2
Staphylococcus aureus
-
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
?
protoheme + 4 AH2 + 4 O2
Staphylococcus aureus N315
-
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
?
protoheme + 4 AH2 + 4 O2
Staphylococcus aureus N315
-
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
?
protoheme + 4 AH2 + 4 O2
Staphylococcus aureus N315
-
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
?
protoheme + 4 AH2 + 4 O2
Staphylococcus aureus N315
-
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
in the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus N315
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus N315
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
in the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus N315
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
in the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus N315
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus N315
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
in the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
protoheme + 4 AH2 + 4 O2
-
725532
Staphylococcus aureus N315
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins
-
-
?
General Information
General Information
Commentary
Organism
physiological function
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid; oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid
Staphylococcus aureus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid
Staphylococcus aureus
Other publictions for EC 1.14.99.48
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740954
Conger
Tight binding of heme to Staph ...
Staphylococcus aureus
Metallomics
9
556-563
2017
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740760
Streit
Time-resolved studies of IsdG ...
Staphylococcus aureus, Staphylococcus aureus N315
J. Biol. Chem.
291
862-871
2016
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740768
Lockhart
Hydrogen bond donation to the ...
Staphylococcus aureus, Staphylococcus aureus MW2
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725532
Loutet
IruO is a reductase for heme d ...
Staphylococcus aureus, Staphylococcus aureus N315
J. Biol. Chem.
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2013
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740058
Matsui
Heme degradation by Staphyloco ...
Staphylococcus aureus
Biochemistry
52
3025-3027
2013
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740703
Ukpabi
Inactivation of the heme degra ...
Staphylococcus aureus, Staphylococcus aureus N315
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34179-34188
2012
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4
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Staphylococcus lugdunensis Isd ...
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740051
Reniere
The flexible loop of Staphyloc ...
Staphylococcus aureus, Staphylococcus aureus Newman
Biochemistry
50
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2011
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2
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725997
Reniere
The IsdG-family of haem oxygen ...
Staphylococcus aureus, Staphylococcus aureus N315
Mol. Microbiol.
75
1529-1538
2010
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Lee
Ruffling of metalloporphyrins ...
Staphylococcus aureus
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725994
Reniere
Staphylococcus aureus haem oxy ...
Staphylococcus aureus, Staphylococcus aureus N315
Mol. Microbiol.
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2008
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Wu
Staphylococcus aureus IsdG and ...
Staphylococcus aureus, Staphylococcus aureus ATCC 700699, Staphylococcus aureus MW2
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725362
Skaar
IsdG and IsdI, heme-degrading ...
Staphylococcus aureus, Staphylococcus aureus N315
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279
436-443
2004
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