BRENDA - Enzyme Database show
show all sequences of 1.14.99.4

Channel catfish liver monooxygenases. Immunological characterization of constitutive cytochromes P450 and the absence of active flavin-containing monooxygenases

Schlenk, D.; Ronis, M.J.J.; Miranda, C.L.; Buhler, D.R.; Biochem. Pharmacol. 45, 217-221 (1993)

Data extracted from this reference:

Application
Application
Commentary
Organism
nutrition
multiple drugs, pesticides and therapeutic agents are used in aquaculturing of channel catfish, flavin-containing monooxygenase enzymatic systems can metabolize these chemicals in the fish
Ictalurus punctatus
nutrition
enzyme plays a significant role in biotransformation of pesticides in rainbow trout
Oncorhynchus mykiss
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Oncorhynchus mykiss
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
Progesterone + NADPH + O2
Sus scrofa
-
Testosterone acetate + NADP+ + H2O
-
Sus scrofa
?
Progesterone + NADPH + O2
Oryctolagus cuniculus
-
Testosterone acetate + NADP+ + H2O
-
Oryctolagus cuniculus
?
Progesterone + NADPH + O2
Oncorhynchus mykiss
-
Testosterone acetate + NADP+ + H2O
-
Oncorhynchus mykiss
?
Progesterone + NADPH + O2
Ictalurus punctatus
-
Testosterone acetate + NADP+ + H2O
-
Ictalurus punctatus
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Ictalurus punctatus
-
channel catfish
-
Oncorhynchus mykiss
-
rainbow trout
-
Oryctolagus cuniculus
-
rabbit
-
Sus scrofa
-
pig
-
Purification (Commentary)
Commentary
Organism
-
Oncorhynchus mykiss
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Ictalurus punctatus
-
liver
-
Oncorhynchus mykiss
-
liver
-
Sus scrofa
-
lung
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Progesterone + NADPH + O2
-
438217
Sus scrofa
Testosterone acetate + NADP+ + H2O
-
438217
Sus scrofa
?
Progesterone + NADPH + O2
-
438217
Oryctolagus cuniculus
Testosterone acetate + NADP+ + H2O
-
438217
Oryctolagus cuniculus
?
Progesterone + NADPH + O2
-
438217
Oncorhynchus mykiss
Testosterone acetate + NADP+ + H2O
-
438217
Oncorhynchus mykiss
?
Progesterone + NADPH + O2
-
438217
Ictalurus punctatus
Testosterone acetate + NADP+ + H2O
-
438217
Ictalurus punctatus
?
testosterone + NADPH + O2
-
438217
Oryctolagus cuniculus
6beta-hydroxytestosterone + NADP+ + H2O
-
438217
Oryctolagus cuniculus
?
testosterone + NADPH + O2
-
438217
Ictalurus punctatus
6beta-hydroxytestosterone + NADP+ + H2O
-
438217
Ictalurus punctatus
?
Cofactor
Cofactor
Commentary
Organism
Structure
cytochrome P450
-
Ictalurus punctatus
cytochrome P450
-
Oncorhynchus mykiss
Application (protein specific)
Application
Commentary
Organism
nutrition
multiple drugs, pesticides and therapeutic agents are used in aquaculturing of channel catfish, flavin-containing monooxygenase enzymatic systems can metabolize these chemicals in the fish
Ictalurus punctatus
nutrition
enzyme plays a significant role in biotransformation of pesticides in rainbow trout
Oncorhynchus mykiss
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
cytochrome P450
-
Ictalurus punctatus
cytochrome P450
-
Oncorhynchus mykiss
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Oncorhynchus mykiss
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
Progesterone + NADPH + O2
Sus scrofa
-
Testosterone acetate + NADP+ + H2O
-
Sus scrofa
?
Progesterone + NADPH + O2
Oryctolagus cuniculus
-
Testosterone acetate + NADP+ + H2O
-
Oryctolagus cuniculus
?
Progesterone + NADPH + O2
Oncorhynchus mykiss
-
Testosterone acetate + NADP+ + H2O
-
Oncorhynchus mykiss
?
Progesterone + NADPH + O2
Ictalurus punctatus
-
Testosterone acetate + NADP+ + H2O
-
Ictalurus punctatus
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Oncorhynchus mykiss
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Ictalurus punctatus
-
liver
-
Oncorhynchus mykiss
-
liver
-
Sus scrofa
-
lung
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Progesterone + NADPH + O2
-
438217
Sus scrofa
Testosterone acetate + NADP+ + H2O
-
438217
Sus scrofa
?
Progesterone + NADPH + O2
-
438217
Oryctolagus cuniculus
Testosterone acetate + NADP+ + H2O
-
438217
Oryctolagus cuniculus
?
Progesterone + NADPH + O2
-
438217
Oncorhynchus mykiss
Testosterone acetate + NADP+ + H2O
-
438217
Oncorhynchus mykiss
?
Progesterone + NADPH + O2
-
438217
Ictalurus punctatus
Testosterone acetate + NADP+ + H2O
-
438217
Ictalurus punctatus
?
testosterone + NADPH + O2
-
438217
Oryctolagus cuniculus
6beta-hydroxytestosterone + NADP+ + H2O
-
438217
Oryctolagus cuniculus
?
testosterone + NADPH + O2
-
438217
Ictalurus punctatus
6beta-hydroxytestosterone + NADP+ + H2O
-
438217
Ictalurus punctatus
?
Other publictions for EC 1.14.99.4
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
715071
Longo
Cisplatin induced toxicity in ...
Rattus norvegicus, Rattus norvegicus Wistar
Food Chem. Toxicol.
49
233-237
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-
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-
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1
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166
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2
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1
1
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659812
Lenasi
Specific interactions of stero ...
Rhizopus stolonifer
J. Steroid Biochem. Mol. Biol.
91
273-284
2004
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-
-
-
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1
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438220
Berrie
Purification and characterizat ...
Streptomyces roseochromogenes
Biochem. Soc. Trans.
25
18S
1997
1
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1
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1
1
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2
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1
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2
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1
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1
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1
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1
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1
1
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-
1
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-
-
2
-
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-
-
-
-
-
438221
Hua
cDNA cloning, heterologous exp ...
Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
Arch. Biochem. Biophys.
340
208-214
1997
-
-
1
-
-
-
-
2
1
-
-
3
-
7
-
-
-
-
-
4
-
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7
-
-
-
-
-
-
-
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-
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-
1
-
-
-
-
-
-
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2
1
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3
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4
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7
-
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-
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438219
Straub
Differential effects of mutati ...
Chlorocebus aethiops
Biochemistry
33
8029-8034
1994
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-
-
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-
-
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1
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2
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1
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1
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1
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
438217
Schlenk
Channel catfish liver monooxyg ...
Ictalurus punctatus, Oncorhynchus mykiss, Oryctolagus cuniculus, Sus scrofa
Biochem. Pharmacol.
45
217-221
1993
-
2
-
-
-
-
-
-
1
-
-
4
-
4
-
-
1
-
-
4
-
-
6
-
-
-
-
-
-
-
-
2
-
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-
-
2
-
2
-
-
-
-
-
-
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1
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-
4
-
-
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1
-
4
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438218
Straub
Hydrophobic side chain require ...
Chlorocebus aethiops
Arch. Biochem. Biophys.
306
521-527
1993
-
-
-
-
-
-
-
-
-
-
-
1
-
1
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1
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
438216
Rahim
Mechanisms of steroid oxidatio ...
Amorphotheca resinae, Ilyonectria destructans, Ilyonectria destructans ACC 11011
J. Biol. Chem.
241
3615-3623
1966
-
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-
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4
4
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3
-
3
-
-
1
-
-
-
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2
13
-
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-
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1
-
2
1
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1
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4
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4
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3
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1
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2
13
-
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1
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2
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