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Literature summary for 1.14.99.38 extracted from

  • Tsujioka, T.; Yokoi, A.; Itano, Y.; Takahashi, K.; Ouchida, M.; Okamoto, S.; Kondo, T.; Suemori, S.; Tohyama, Y.; Tohyama, K.
    Five-aza-2-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells (2015), Sci. Rep., 5, 16709 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + AH2 + O2 Homo sapiens
-
 25-hydroxycholesterol + A + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q95992
-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:CD34+ cell
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-
MDS-92 cell
-
 Homo sapiens
-
MDS-L cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + AH2 + O2
-
 Homo sapiens 25-hydroxycholesterol + A + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CH25H
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme mRNA expression level is originally low in myelodysplasia/leukemia cell lines. Enzyme knockdown partially protects the cells from decitabine-induced cell death down
Homo sapiens exposure to DNA methyltransferase inhibitors and decitabine enhances enzyme mRNA expression in myelodysplasia/leukemia cell lines up

General Information

General Information Comment Organism
malfunction decitabine-induced hypomethylation of the cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells Homo sapiens