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Literature summary for 1.14.99.38 extracted from

  • Liu, S.Y.; Aliyari, R.; Chikere, K.; Li, G.; Marsden, M.D.; Smith, J.K.; Pernet, O.; Guo, H.; Nusbaum, R.; Zack, J.A.; Freiberg, A.N.; Su, L.; Lee, B.; Cheng, G.
    Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol (2013), Immunity, 38, 92-105.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene CH25H, overexpression in HEK-293T cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + AH2 + O2 Mus musculus
-
 25-hydroxycholesterol + A + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9Z0F5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow-derived macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + AH2 + O2
-
 Mus musculus 25-hydroxycholesterol + A + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CH25H
-
 Mus musculus
cholesterol-25-hydroxylase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus both IFN-alpha- and IFN-gamma induce the enzyme in bone marrow-derived macrophages up

General Information

General Information Comment Organism
malfunction loss of function of Ch25h leads to susceptibility to viral infections in vitro Mus musculus
physiological function cholesterol-25-hydroxylase acts as a broadly antiviral interferon-stimulated gene. CH25H converts cholesterol to a soluble antiviral factor, 25-hydroxycholesterol. 25-Hydroxycholesterol treatment in cultured cells broadly inhibits growth of enveloped viruses including VSV, HSV, HIV, and MHV68 and acutely pathogenic EBOV, RVFV, RSSEV, and Nipah viruses. The compound inhibits cell entry of viruses HIV and VSV, and inhibits viral protein-mediated cell-cell membrane fusion of virus NIV. 25-Hydroxycholesterol directly modifies membranes Mus musculus