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Literature summary for 1.14.99.38 extracted from
- Genomics and proteomics of vertebrate cholesterol ester lipase (LIPA) and cholesterol 25-hydroxylase (CH25H) (2011), 3 Biotech, 1, 99-109.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene CH25H, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10 | Xenopus tropicalis |
| intronless gene CH25H is located on chromosome 1, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10 | Rattus norvegicus |
| intronless gene CH25H is located on chromosome 1, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10 | Equus caballus |
| intronless gene CH25H is located on chromosome 10, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10 | Homo sapiens |
| intronless gene CH25H is located on chromosome 19, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10 | Mus musculus |
| intronless gene CH25H is located on chromosome 26, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10 | Canis lupus familiaris |
| intronless gene CH25H is located on chromosome 26, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10 | Bos taurus |
| intronless gene CH25H is located on chromosome 6, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10 | Gallus gallus |
| intronless gene CH25H is located on chromosome 9, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10 | Macaca mulatta |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum membrane | transmembrane enzyme, prediction of transmembrane structures for CH25H subunits, overview | Gallus gallus | 5789 | - |
| endoplasmic reticulum membrane | transmembrane enzyme, prediction of transmembrane structures for CH25H subunits, overview | Canis lupus familiaris | 5789 | - |
| endoplasmic reticulum membrane | transmembrane enzyme, prediction of transmembrane structures for CH25H subunits, overview | Mus musculus | 5789 | - |
| endoplasmic reticulum membrane | transmembrane enzyme, prediction of transmembrane structures for CH25H subunits, overview | Homo sapiens | 5789 | - |
| endoplasmic reticulum membrane | transmembrane enzyme, prediction of transmembrane structures for CH25H subunits, overview | Xenopus tropicalis | 5789 | - |
| endoplasmic reticulum membrane | transmembrane enzyme, prediction of transmembrane structures for CH25H subunits, overview | Macaca mulatta | 5789 | - |
| endoplasmic reticulum membrane | transmembrane enzyme, prediction of transmembrane structures for CH25H subunits, overview | Rattus norvegicus | 5789 | - |
| endoplasmic reticulum membrane | transmembrane enzyme, prediction of transmembrane structures for CH25H subunits, overview | Equus caballus | 5789 | - |
| endoplasmic reticulum membrane | transmembrane enzyme, prediction of transmembrane structures for CH25H subunits, overview | Bos taurus | 5789 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | the enzyme contains a di-iron cofactor | Gallus gallus |  |
| Fe2+ | the enzyme contains a di-iron cofactor | Canis lupus familiaris | |
| Fe2+ | the enzyme contains a di-iron cofactor | Mus musculus | |
| Fe2+ | the enzyme contains a di-iron cofactor | Homo sapiens | |
| Fe2+ | the enzyme contains a di-iron cofactor | Xenopus tropicalis | |
| Fe2+ | the enzyme contains a di-iron cofactor | Macaca mulatta | |
| Fe2+ | the enzyme contains a di-iron cofactor | Rattus norvegicus | |
| Fe2+ | the enzyme contains a di-iron cofactor | Equus caballus | |
| Fe2+ | the enzyme contains a di-iron cofactor | Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 30426 | - |
x * 30426, sequence calculation | Canis lupus familiaris |
| 31326 | - |
x * 31326, sequence calculation | Bos taurus |
| 31405 | - |
x * 31405, sequence calculation | Xenopus tropicalis |
| 31464 | - |
x * 31464, sequence calculation | Equus caballus |
| 31745 | - |
x * 31745, sequence calculation | Homo sapiens |
| 31850 | - |
x * 31850, sequence calculation | Macaca mulatta |
| 32456 | - |
x * 32456, sequence calculation | Gallus gallus |
| 34414 | - |
x * 34414, sequence calculation | Rattus norvegicus |
| 34672 | - |
x * 34672, sequence calculation | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesterol + AH2 + O2 | Gallus gallus | - |
25-hydroxycholesterol + A + H2O | - |
? | |
| cholesterol + AH2 + O2 | Canis lupus familiaris | - |
25-hydroxycholesterol + A + H2O | - |
? | |
| cholesterol + AH2 + O2 | Mus musculus | - |
25-hydroxycholesterol + A + H2O | - |
? | |
| cholesterol + AH2 + O2 | Homo sapiens | - |
25-hydroxycholesterol + A + H2O | - |
? | |
| cholesterol + AH2 + O2 | Xenopus tropicalis | - |
25-hydroxycholesterol + A + H2O | - |
? | |
| cholesterol + AH2 + O2 | Macaca mulatta | - |
25-hydroxycholesterol + A + H2O | - |
? | |
| cholesterol + AH2 + O2 | Rattus norvegicus | - |
25-hydroxycholesterol + A + H2O | - |
? | |
| cholesterol + AH2 + O2 | Equus caballus | - |
25-hydroxycholesterol + A + H2O | - |
? | |
| cholesterol + AH2 + O2 | Bos taurus | - |
25-hydroxycholesterol + A + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | Q0P599 | - |
- |
| Canis lupus familiaris | - |
- |
- |
| Equus caballus | F6T000 | - |
- |
| Gallus gallus | - |
- |
- |
| Homo sapiens | O95992 | - |
- |
| Macaca mulatta | F7EC50 | - |
- |
| Mus musculus | Q9Z0F5 | - |
- |
| Rattus norvegicus | Q4QQV7 | - |
- |
| Xenopus tropicalis | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Gallus gallus | - |
| liver | - |
Canis lupus familiaris | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Xenopus tropicalis | - |
| liver | - |
Macaca mulatta | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Equus caballus | - |
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesterol + AH2 + O2 | - |
Gallus gallus | 25-hydroxycholesterol + A + H2O | - |
? | |
| cholesterol + AH2 + O2 | - |
Canis lupus familiaris | 25-hydroxycholesterol + A + H2O | - |
? | |
| cholesterol + AH2 + O2 | - |
Mus musculus | 25-hydroxycholesterol + A + H2O | - |
? | |
| cholesterol + AH2 + O2 | - |
Homo sapiens | 25-hydroxycholesterol + A + H2O | - |
? | |
| cholesterol + AH2 + O2 | - |
Xenopus tropicalis | 25-hydroxycholesterol + A + H2O | - |
? | |
| cholesterol + AH2 + O2 | - |
Macaca mulatta | 25-hydroxycholesterol + A + H2O | - |
? | |
| cholesterol + AH2 + O2 | - |
Rattus norvegicus | 25-hydroxycholesterol + A + H2O | - |
? | |
| cholesterol + AH2 + O2 | - |
Equus caballus | 25-hydroxycholesterol + A + H2O | - |
? | |
| cholesterol + AH2 + O2 | - |
Bos taurus | 25-hydroxycholesterol + A + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 30426, sequence calculation | Canis lupus familiaris |
| ? | x * 31326, sequence calculation | Bos taurus |
| ? | x * 31405, sequence calculation | Xenopus tropicalis |
| ? | x * 31464, sequence calculation | Equus caballus |
| ? | x * 31745, sequence calculation | Homo sapiens |
| ? | x * 31850, sequence calculation | Macaca mulatta |
| ? | x * 32456, sequence calculation | Gallus gallus |
| ? | x * 34414, sequence calculation | Rattus norvegicus |
| ? | x * 34672, sequence calculation | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CH25H | - |
Gallus gallus |
| CH25H | - |
Canis lupus familiaris |
| CH25H | - |
Mus musculus |
| CH25H | - |
Homo sapiens |
| CH25H | - |
Xenopus tropicalis |
| CH25H | - |
Macaca mulatta |
| CH25H | - |
Rattus norvegicus |
| CH25H | - |
Equus caballus |
| CH25H | - |
Bos taurus |
| cholesterol 25-monooxygenase | - |
Gallus gallus |
| cholesterol 25-monooxygenase | - |
Canis lupus familiaris |
| cholesterol 25-monooxygenase | - |
Mus musculus |
| cholesterol 25-monooxygenase | - |
Homo sapiens |
| cholesterol 25-monooxygenase | - |
Xenopus tropicalis |
| cholesterol 25-monooxygenase | - |
Macaca mulatta |
| cholesterol 25-monooxygenase | - |
Rattus norvegicus |
| cholesterol 25-monooxygenase | - |
Equus caballus |
| cholesterol 25-monooxygenase | - |
Bos taurus |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Equus caballus | sequence calculation | - |
6.73 |
| Macaca mulatta | sequence calculation | - |
6.75 |
| Homo sapiens | sequence calculation | - |
6.77 |
| Bos taurus | sequence calculation | - |
6.88 |
| Rattus norvegicus | sequence calculation | - |
7.07 |
| Mus musculus | sequence calculation | - |
7.67 |
| Gallus gallus | sequence calculation | - |
8.15 |
| Xenopus tropicalis | sequence calculation | - |
8.61 |
| Canis lupus familiaris | sequence calculation | - |
8.88 |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis | Gallus gallus |
| physiological function | cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis | Canis lupus familiaris |
| physiological function | cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis | Mus musculus |
| physiological function | cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis | Homo sapiens |
| physiological function | cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis | Xenopus tropicalis |
| physiological function | cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis | Macaca mulatta |
| physiological function | cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis | Rattus norvegicus |
| physiological function | cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis | Equus caballus |
| physiological function | cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis | Bos taurus |
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