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Literature summary for 1.14.99.29 extracted from

  • Jasniewski, A.J.; Engstrom, L.M.; Vu, V.V.; Park, M.H.; Que, L.
    X-ray absorption spectroscopic characterization of the diferric-peroxo intermediate of human deoxyhypusine hydroxylase in the presence of its substrate eIF5a (2016), J. Biol. Inorg. Chem., 21, 605-618 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3)pLysS cells Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ non-heme diiron enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[eIF5A]-deoxyhypusine + AH2 + O2 Homo sapiens
-
[eIF5A]-hypusine + A + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BU89
-
-

Purification (Commentary)

Purification (Comment) Organism
GSH-Sepharose resin column chromatography and Superdex 200 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[eIF5A]-deoxyhypusine + AH2 + O2
-
Homo sapiens [eIF5A]-hypusine + A + H2O
-
?

Synonyms

Synonyms Comment Organism
deoxyhypusine hydroxylase
-
Homo sapiens
DOHH
-
Homo sapiens