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Literature summary for 1.14.99.29 extracted from

  • Hoque, M.; Hanauske-Abel, H.M.; Palumbo, P.; Saxena, D.; DAlliessi Gandolfi, D.; Park, M.H.; Peery, T.; Mathews, M.B.
    Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A (2009), Retrovirology, 6, 90.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the results support the concept that drugs targeting DOHH should be tested clinically for HIV-1 inhibition and could be developed as antiretrovirals Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ciclopirox CPX, topical fungicide Homo sapiens
deferiprone DEF, systemic medicinal iron chelator Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens DOHH hydroxylates the deoxyhypusyl-eukaryotic translation initiation factor eIF5A intermediate to hyposine-containing mature eIF5A using molecular oxygen ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PBMC cell line
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information DOHH hydroxylates the deoxyhypusyl-eukaryotic translation initiation factor eIF5A intermediate to hyposine-containing mature eIF5A using molecular oxygen Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
deoxyhypusine hydroxylase
-
Homo sapiens
DOHH
-
Homo sapiens