BRENDA - Enzyme Database show
show all sequences of 1.14.99.19

Orphan enzymes in ether lipid metabolism

Watschinger, K.; Werner, E.R.; Biochimie 95, 59-65 (2013)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
bound
Homo sapiens
16020
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2
Homo sapiens
i.e. plasmanylethanolamine
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O
i.e. plasmenylethanolamine
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
the enzyme converts plasmanylethanolamine into plasmenylethanolamine by introducing a vinyl double bound. It requires cytochrome b5, molecular oxygen and either NADPH or NADH as cofactors for functional catalysis. Plasmanylcholines are no substrates for plasmanylethanolamine desaturase
727110
Homo sapiens
?
-
-
-
-
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2
i.e. plasmanylethanolamine
727110
Homo sapiens
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O
i.e. plasmenylethanolamine
-
-
?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + reduced cytochrome b5 + O2
i.e. plasmanylethanolamine, the reaction involves reaction involving cytochrome b5 reductase, molecular oxygen and a reduction equivalent
727110
Homo sapiens
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized cytochrome b5 + 2 H2O
i.e. plasmenylethanolamine
-
-
?
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
bound
Homo sapiens
16020
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2
Homo sapiens
i.e. plasmanylethanolamine
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O
i.e. plasmenylethanolamine
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
the enzyme converts plasmanylethanolamine into plasmenylethanolamine by introducing a vinyl double bound. It requires cytochrome b5, molecular oxygen and either NADPH or NADH as cofactors for functional catalysis. Plasmanylcholines are no substrates for plasmanylethanolamine desaturase
727110
Homo sapiens
?
-
-
-
-
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2
i.e. plasmanylethanolamine
727110
Homo sapiens
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O
i.e. plasmenylethanolamine
-
-
?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + reduced cytochrome b5 + O2
i.e. plasmanylethanolamine, the reaction involves reaction involving cytochrome b5 reductase, molecular oxygen and a reduction equivalent
727110
Homo sapiens
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized cytochrome b5 + 2 H2O
i.e. plasmenylethanolamine
-
-
?
General Information
General Information
Commentary
Organism
metabolism
plasmanylethanolamine desaturase is a key enzyme for the biosynthesis of one of the most abundant phospholipidsin the body, the plasmalogens. Ether lipid metabolism including biosynthesis and degradation of platelet-activating factor and plasmalogens, overview
Homo sapiens
additional information
the enzyme is a defined enzyme without assigned sequence, these kind of enzymes are known as orphan enzymes
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
metabolism
plasmanylethanolamine desaturase is a key enzyme for the biosynthesis of one of the most abundant phospholipidsin the body, the plasmalogens. Ether lipid metabolism including biosynthesis and degradation of platelet-activating factor and plasmalogens, overview
Homo sapiens
additional information
the enzyme is a defined enzyme without assigned sequence, these kind of enzymes are known as orphan enzymes
Homo sapiens
Other publictions for EC 1.14.99.19
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
727110
Watschinger
Orphan enzymes in ether lipid ...
Homo sapiens
Biochimie
95
59-65
2013
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438318
Das
A novel chemical synthesis of ...
Rattus norvegicus
J. Lipid Res.
37
2706-2714
1996
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438319
Blank
Plasmanylethanolamine D1-desat ...
Mesocricetus auratus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
Methods Enzymol.
209
390-396
1992
4
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438316
Weber
Formation of ether lipids and ...
Mus musculus, Rattus norvegicus
Biochim. Biophys. Acta
711
197-207
1982
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438315
Wykle
Biosynthesis of plasmalogens b ...
Rattus norvegicus
Biochemistry
18
3512-3517
1979
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438317
Baumann
On the substrate specificity o ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
66
717-724
1975
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438312
Paltauf
Enzymatic synthesis of plasmal ...
Mesocricetus auratus
J. Biol. Chem.
248
1609-1615
1973
1
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438314
Lee
Dietary control of stearyl CoA ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
55
574-579
1973
1
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438313
Wykle
Evidence for a mixed function ...
Rattus norvegicus
J. Biol. Chem.
247
5442-5447
1972
2
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