BRENDA - Enzyme Database show
show all sequences of 1.14.99.19

Plasmanylethanolamine D1-desaturase

Blank, M.L.; Snyder, F.; Methods Enzymol. 209, 390-396 (1992)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
catalase
-
Mesocricetus auratus
catalase
-
Mus musculus
catalase
-
Oryctolagus cuniculus
catalase
-
Rattus norvegicus
General Stability
General Stability
Organism
activity loss at -23°C, should be used freshly
Rattus norvegicus
Inhibitors
Inhibitors
Commentary
Organism
Structure
CN-
be not inhibited by carbon monoxide
Mesocricetus auratus
CN-
be not inhibited by carbon monoxide
Mus musculus
CN-
be not inhibited by carbon monoxide
Oryctolagus cuniculus
CN-
be not inhibited by carbon monoxide
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
microsomal membrane, advisable to check the effect of the soluble fraction
Mesocricetus auratus
-
-
microsome
microsomal membrane, advisable to check the effect of the soluble fraction
Mus musculus
-
-
microsome
microsomal membrane, advisable to check the effect of the soluble fraction
Oryctolagus cuniculus
-
-
microsome
microsomal membrane, advisable to check the effect of the soluble fraction
Rattus norvegicus
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mesocricetus auratus
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
ascites
-
Mus musculus
-
ascites
Ehrlich cells
Rattus norvegicus
-
brain
-
Rattus norvegicus
-
P-388D1 cell
-
Mus musculus
-
sarcoma cell
Fischer R-3259 sarcoma
Rattus norvegicus
-
small intestine mucosa
-
Mesocricetus auratus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
electron donors: NADPH or NADH
438319
Mus musculus
?
-
-
-
-
additional information
electron donors: NADPH or NADH
438319
Rattus norvegicus
?
-
-
-
-
additional information
electron donors: NADPH or NADH
438319
Oryctolagus cuniculus
?
-
-
-
-
additional information
electron donors: NADPH or NADH
438319
Mesocricetus auratus
?
-
-
-
-
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
generated in situ by microsomal acylation of alkyllyso-glycero-3-phosphoethanolamine, better substrate than when it is added exogenously
438319
Mus musculus
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
-
-
-
?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
generated in situ by microsomal acylation of alkyllyso-glycero-3-phosphoethanolamine, better substrate than when it is added exogenously
438319
Rattus norvegicus
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
-
-
-
?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
generated in situ by microsomal acylation of alkyllyso-glycero-3-phosphoethanolamine, better substrate than when it is added exogenously
438319
Oryctolagus cuniculus
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
-
-
-
?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
generated in situ by microsomal acylation of alkyllyso-glycero-3-phosphoethanolamine, better substrate than when it is added exogenously
438319
Mesocricetus auratus
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
enzyme assay
Mesocricetus auratus
37
-
-
Mus musculus
37
-
-
Oryctolagus cuniculus
37
-
enzyme assay
Rattus norvegicus
Cofactor
Cofactor
Commentary
Organism
Structure
cytochrome b5
-
Mesocricetus auratus
cytochrome b5
-
Mus musculus
cytochrome b5
-
Oryctolagus cuniculus
cytochrome b5
-
Rattus norvegicus
NADPH
or NADH
Mesocricetus auratus
NADPH
or NADH
Mus musculus
NADPH
or NADH
Oryctolagus cuniculus
NADPH
or NADH
Rattus norvegicus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
catalase
-
Mesocricetus auratus
catalase
-
Mus musculus
catalase
-
Oryctolagus cuniculus
catalase
-
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
cytochrome b5
-
Mesocricetus auratus
cytochrome b5
-
Mus musculus
cytochrome b5
-
Oryctolagus cuniculus
cytochrome b5
-
Rattus norvegicus
NADPH
or NADH
Mesocricetus auratus
NADPH
or NADH
Mus musculus
NADPH
or NADH
Oryctolagus cuniculus
NADPH
or NADH
Rattus norvegicus
General Stability (protein specific)
General Stability
Organism
activity loss at -23°C, should be used freshly
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
CN-
be not inhibited by carbon monoxide
Mesocricetus auratus
CN-
be not inhibited by carbon monoxide
Mus musculus
CN-
be not inhibited by carbon monoxide
Oryctolagus cuniculus
CN-
be not inhibited by carbon monoxide
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
microsomal membrane, advisable to check the effect of the soluble fraction
Mesocricetus auratus
-
-
microsome
microsomal membrane, advisable to check the effect of the soluble fraction
Mus musculus
-
-
microsome
microsomal membrane, advisable to check the effect of the soluble fraction
Oryctolagus cuniculus
-
-
microsome
microsomal membrane, advisable to check the effect of the soluble fraction
Rattus norvegicus
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
ascites
-
Mus musculus
-
ascites
Ehrlich cells
Rattus norvegicus
-
brain
-
Rattus norvegicus
-
P-388D1 cell
-
Mus musculus
-
sarcoma cell
Fischer R-3259 sarcoma
Rattus norvegicus
-
small intestine mucosa
-
Mesocricetus auratus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
electron donors: NADPH or NADH
438319
Mus musculus
?
-
-
-
-
additional information
electron donors: NADPH or NADH
438319
Rattus norvegicus
?
-
-
-
-
additional information
electron donors: NADPH or NADH
438319
Oryctolagus cuniculus
?
-
-
-
-
additional information
electron donors: NADPH or NADH
438319
Mesocricetus auratus
?
-
-
-
-
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
generated in situ by microsomal acylation of alkyllyso-glycero-3-phosphoethanolamine, better substrate than when it is added exogenously
438319
Mus musculus
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
-
-
-
?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
generated in situ by microsomal acylation of alkyllyso-glycero-3-phosphoethanolamine, better substrate than when it is added exogenously
438319
Rattus norvegicus
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
-
-
-
?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
generated in situ by microsomal acylation of alkyllyso-glycero-3-phosphoethanolamine, better substrate than when it is added exogenously
438319
Oryctolagus cuniculus
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
-
-
-
?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
generated in situ by microsomal acylation of alkyllyso-glycero-3-phosphoethanolamine, better substrate than when it is added exogenously
438319
Mesocricetus auratus
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
enzyme assay
Mesocricetus auratus
37
-
-
Mus musculus
37
-
-
Oryctolagus cuniculus
37
-
enzyme assay
Rattus norvegicus
Other publictions for EC 1.14.99.19
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
727110
Watschinger
Orphan enzymes in ether lipid ...
Homo sapiens
Biochimie
95
59-65
2013
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
438318
Das
A novel chemical synthesis of ...
Rattus norvegicus
J. Lipid Res.
37
2706-2714
1996
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
2
1
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
2
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
438319
Blank
Plasmanylethanolamine D1-desat ...
Mesocricetus auratus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
Methods Enzymol.
209
390-396
1992
4
-
-
-
-
1
4
-
4
-
-
-
-
4
-
-
-
-
-
6
-
-
8
-
4
-
-
-
-
-
-
8
-
-
-
4
-
-
8
-
-
1
-
4
-
-
4
-
-
-
-
-
-
-
-
6
-
-
8
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
438316
Weber
Formation of ether lipids and ...
Mus musculus, Rattus norvegicus
Biochim. Biophys. Acta
711
197-207
1982
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
1
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438315
Wykle
Biosynthesis of plasmalogens b ...
Rattus norvegicus
Biochemistry
18
3512-3517
1979
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438317
Baumann
On the substrate specificity o ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
66
717-724
1975
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
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-
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1
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438312
Paltauf
Enzymatic synthesis of plasmal ...
Mesocricetus auratus
J. Biol. Chem.
248
1609-1615
1973
1
-
-
-
-
-
10
-
1
1
-
1
-
1
-
-
-
1
-
1
1
-
3
-
1
-
-
-
1
-
-
2
-
-
-
1
-
-
2
-
-
-
-
10
-
-
1
1
-
1
-
-
-
-
-
1
1
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
438314
Lee
Dietary control of stearyl CoA ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
55
574-579
1973
1
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
-
1
2
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
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-
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438313
Wykle
Evidence for a mixed function ...
Rattus norvegicus
J. Biol. Chem.
247
5442-5447
1972
2
-
-
-
-
-
1
-
-
1
-
1
-
1
-
-
-
1
-
1
-
1
1
-
1
-
-
-
-
-
-
3
-
-
-
2
-
-
3
-
-
-
-
1
-
-
-
1
-
1
-
-
-
-
-
1
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-