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Literature summary for 1.14.99.1 extracted from

  • Tsai, A.L.; Kulmacz, R.J.
    Prostaglandin H synthase: Resolved and unresolved mechanistic issues (2010), Arch. Biochem. Biophys., 493, 103-124.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0009
-
arachidonate purified isoform PGHS-2, method: coupled, homo-vanilic acid Homo sapiens
0.0011
-
arachidonate purified isoform PGHS-2, method: direct, O2 Homo sapiens
0.0017
-
arachidonate purified isoform PGHS-2, method: direct, O2 Homo sapiens
0.0019
-
arachidonate purified isoform PGHS-1, method: direct, O2 Ovis aries
0.002
-
arachidonate purified isoform PGHS-2, method: direct, O2 Homo sapiens
0.0027
-
arachidonate purified isoform PGHS-1, method: coupled, homo-vanilic acid Ovis aries
0.003
-
arachidonate purified isoform PGHS-1, method: direct, O2 Ovis aries
0.0037
-
arachidonate purified isoform PGHS-1, method: direct, O2 Ovis aries
0.0045
-
arachidonate purified isoform PGHS-1, method: direct, O2 Homo sapiens
0.005
-
O2 purified isoform PGHS-1, method: direct, O2 Ovis aries
0.005
-
arachidonate purified isoform PGHS-2, method: direct, O2 Homo sapiens
0.0051
-
arachidonate purified isoform PGHS-2, method: direct, O2 Homo sapiens
0.0055
-
O2 purified isoform PGHS-1, method: direct, O2 Ovis aries
0.009
-
arachidonate purified isoform PGHS-2, method: direct, O2 Homo sapiens
0.0092
-
arachidonate purified isoform PGHS-2, method: direct, O2 Homo sapiens
0.01
-
O2 purified isoform PGHS-1, method: direct, arachidonate Ovis aries
0.01
-
arachidonate purified isoform PGHS-2, method: direct, arachidonate Homo sapiens
0.01
-
arachidonate purified isoform PGHS-2, method: direct, trimethyl phosphine oxide Homo sapiens
0.0102
-
arachidonate purified isoform PGHS-1, method: direct, arachidonate Homo sapiens
0.011
-
arachidonate purified isoform PGHS-1, method: coupled, homo-vanilic acid Ovis aries
0.011
-
O2 purified isoform PGHS-1, method: direct, O2 Ovis aries
0.015
-
arachidonate purified isoform PGHS-1, method: direct, O2 Ovis aries

Organism

Organism UniProt Comment Textmining
Homo sapiens P23219
-
-
Homo sapiens P35354
-
-
Ovis aries P05979
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
-
Ovis aries

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + AH2 + O2 the reaction comprises two steps: dioxygenation of arachidonate to yield prostaglandin G2 containing both a 9-11 endoperoxide and a 15-peroxide group, and a peroxidase reaction, which converts prostaglandin G2 to prostaglandin H2 where the 15-peroxide is reduced to an alcohol Homo sapiens prostaglandin H2 + A + H2O
-
?
arachidonate + AH2 + O2 the reaction comprises two steps: dioxygenation of arachidonate to yield prostaglandin G2 containing both a 9-11 endoperoxide and a 15-peroxide group, and a peroxidase reaction, which converts prostaglandin G2 to prostaglandin H2 where the 15-peroxide is reduced to an alcohol Ovis aries prostaglandin H2 + A + H2O
-
?

Synonyms

Synonyms Comment Organism
PGHS-1 isoform Ovis aries
PGHS-1 isoform Homo sapiens
PGHS-2 isoform Homo sapiens
prostaglandin H synthase
-
Homo sapiens
prostaglandin H synthase
-
Ovis aries

Cofactor

Cofactor Comment Organism Structure
heme
-
Homo sapiens
heme
-
Ovis aries