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Literature summary for 1.14.99.1 extracted from
- Prostaglandin H synthase-catalyzed bioactivation of amphetamines to free radical intermediates that cause CNS regional DNA oxidation and nerve terminal degeneration (2006), FASEB J., 20, 638-650.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | amphetamines, bioactivated by prostaglandin H synthase, cause reactive oxygen species formation, implicated in amphetamine-initiated neurodegeneration | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Acetylsalicylic acid | - |
Mus musculus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 65000 | - |
immunoblot | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + AH2 + O2 | Mus musculus | - |
prostaglandin H2 + A + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain cortex | - |
Mus musculus | - |
| brain stem | - |
Mus musculus | - |
| cerebellum | - |
Mus musculus | - |
| hippocampus | - |
Mus musculus | - |
| striatum | - |
Mus musculus | - |
| substantia nigra | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + AH2 + O2 | - |
Mus musculus | prostaglandin H2 + A + H2O | - |
? | |
| arachidonic acid + 3,4-methylenedioxyamphetamine | postulated bioactivation to a neurodegenerative free radical intermediate that can initiate the formation of reactive oxygen species | Mus musculus | ? | - |
? | |
| arachidonic acid + 3,4-methylenedioxymethamphetamine | postulated bioactivation to a neurodegenerative free radical intermediate that can initiate the formation of reactive oxygen species | Mus musculus | ? | - |
? | |
| arachidonic acid + methamphetamine | postulated bioactivation to a neurodegenerative free radical intermediate that can initiate the formation of reactive oxygen species | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PHS | - |
Mus musculus |
| PHS-1 | - |
Mus musculus |
| prostaglandin H synthase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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