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Literature summary for 1.14.99.1 extracted from

  • Barnett, J.; Chow, J.; Ives, D.; Chiou, M.; Mackenzie, R.; Osen, E.; Nguyen, B.; Tsing, S.; Bach, C.; Freire, J.; et al.
    Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system (1994), Biochim. Biophys. Acta, 1209, 130-139.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
anirolac isozyme 1, 50% inhibition at 0.0007 mM, isozyme 2, 50% inhibition at 0.009 mM Homo sapiens
diclofenac isozyme 1, 50% inhibition at 0.0009 mM, isozyme 2, 50% inhibition at 0.0015 mM Homo sapiens
fenclofenac isozyme 1, 50% inhibition at 0.007 mM, isozyme 2, 50% inhibition at 0.004 mM Homo sapiens
flurbiprofen isozyme 1, 50% inhibition at 40 nM, isozyme 2, 50% inhibition at 500 nM Homo sapiens
Ibuprofen isozyme 1, 50% inhibition at 0.0026 mM, isozyme 2, 50% inhibition at 0.0015 mM Homo sapiens
indomethacin isozyme 1, 50% inhibition at 0.0017 mM, isozyme 2, 50% inhibition at 0.025 mM Homo sapiens
Ketoprofen isozyme 1, 50% inhibition at 0.0005 mM, isozyme 2, 50% inhibition at 0.0025 mM Homo sapiens
Mefenamic acid isozyme 1, 50% inhibition at 0.01 mM, isozyme 2, 50% inhibition at 0.0003 mM Homo sapiens
N-[2-cyclohexyloxy-4-nitrophenyl]methanesulfonamide isozyme 1, 50% inhibition at 0.075 mM, isozyme 2, 50% inhibition at 0.002 mM Homo sapiens
naproxen isozyme 1, 50% inhibition at 0.0006 mM, isozyme 2, 50% inhibition at 0.002 mM Homo sapiens
niflumic acid isozyme 1, 50% inhibition at 0.016 mM, isozyme 2, 50% inhibition at 0.0001 mM Homo sapiens
nimesulide isozyme 1, 50% inhibition at 0.07 mM, isozyme 2, 50% inhibition at 0.0013 mM Homo sapiens
suprofen isozyme 1, 50% inhibition at 0.0005 mM, isozyme 2, 50% inhibition at 0.002mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0045
-
 arachidonic acid isozyme 1 Homo sapiens
0.005
-
 arachidonic acid isozyme 2 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75000
-
 x * 75000, SDS-PAGE, isozyme 1 and 2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinant isozymes 1 and 2
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein both isozyme 1 and 2 Homo sapiens

Subunits

Subunits Comment Organism
? x * 75000, SDS-PAGE, isozyme 1 and 2 Homo sapiens