Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 | Pseudomonas aeruginosa | - |
(2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + succinate + CO2 + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 | - |
Pseudomonas aeruginosa | (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + succinate + CO2 + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
pvcB | - |
Pseudomonas aeruginosa |
General Information | Comment | Organism |
---|---|---|
physiological function | in the biosynthetis of paerucumarin, PvcA generates an isonitrile-functionalized tyrosine, (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate, that is oxidized by PvcB to give the unsaturated intermediate compound (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate. Oxidation of this compound to a catechol by PvcC/D, followed by intermolecular cyclization of the catechol and the carboxylate, gives paerucumarin. Pseudomonas aeruginosa strains produced a different ratio of paerucumarin to pseudoverdine. PAO1 produces almost exclusively paerucumarin, while PA14 produces approximately a one-to-one mixture of paerucumarin and pseudoverdine | Pseudomonas aeruginosa |