Literature summary for 1.14.20.4 extracted from

Turnbull, J.J.; Nagle, M.J.; Seibel, J.F.; Welford, R.W.; Grant, G.H.; Schofield, C.J.
The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity (2003), Bioorg. Med. Chem. Lett., 13, 3853-3857.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2R,3S,4S-cis-leucoanthocyanidin + 2-oxoglutarate + O2	Arabidopsis thaliana	catalyses the penultimate step in anthocyanin biosynthesis by oxidation of the 2R,3S,4S-cis-leucoanthocyanidins	cis- and trans-dihydroquercetins + succinate + CO2 + 2 H2O	both quercetin and dihydroquercetin are products with the distribution being dependent on the C-4 stereochemistry of the leucocyanidin substrates	?

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2R,3S,4R-trans-leucocyanidin + 2-oxoglutarate + O2	-	Arabidopsis thaliana	2R,3S-cis-dihydroquercetin + 2R,3R-trans-dihydroquercetin + cyanidin + quercetin	55% 2R,3S-cis-dihydroquercetin + 11% 2R,3R-trans-dihydroquercetin + 4% cyanidin + 30% quercetin	?
2R,3S,4S-cis-leucoanthocyanidin + 2-oxoglutarate + O2	catalyses the penultimate step in anthocyanin biosynthesis by oxidation of the 2R,3S,4S-cis-leucoanthocyanidins	Arabidopsis thaliana	cis- and trans-dihydroquercetins + succinate + CO2 + 2 H2O	both quercetin and dihydroquercetin are products with the distribution being dependent on the C-4 stereochemistry of the leucocyanidin substrates	?
2R,3S,4S-cis-leucocyanidin + 2-oxoglutarate + O2	-	Arabidopsis thaliana	2R,3S-cis-dihydroquercetin + 2R,3R-trans-dihydroquercetin + cyanidin + quercetin	10% 2R,3S-cis-dihydroquercetin + 2% 2R,3R-trans-dihydroquercetin + 3% cyanidin + 85% quercetin	?

Synonyms

Synonyms	Comment	Organism
ANS	-	Arabidopsis thaliana
anthocyanidin synthase	-	Arabidopsis thaliana

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Release 2023.1 (January 2023)