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Literature summary for 1.14.20.14 extracted from

  • Zhu, Q.; Hillwig, M.L.; Doi, Y.; Liu, X.
    Aliphatic halogenase enables late-stage C-H functionalization selective synthesis of a brominated Fischerindole alkaloid with enhanced antibacterial activity (2016), ChemBioChem, 17, 466-470 .
    View publication on PubMed
Search for more literature for 1.14.20.14

Application

Application Comment Organism
medicine synthesis of 13R-bromo-12-epi-fischerindole U, which is selective against the gram-positive bacterium Staphylococcus aureus Hapalosiphon welwitschii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
12-epi-fischerindole U + 2-oxoglutarate + O2 + chloride Hapalosiphon welwitschii
-
 12-epi-fischerindole G + succinate + CO2 + H2O
-
 ?
12-epi-fischerindole U + 2-oxoglutarate + O2 + chloride Hapalosiphon welwitschii UTEX B 1830
-
 12-epi-fischerindole G + succinate + CO2 + H2O
-
 ?
12-epi-hapalindole C + 2-oxoglutarate + O2 + chloride Hapalosiphon welwitschii
-
 12-epi-hapalindole E + succinate + CO2 + H2O
-
 ?
12-epi-hapalindole C + 2-oxoglutarate + O2 + chloride Hapalosiphon welwitschii UTEX B 1830
-
 12-epi-hapalindole E + succinate + CO2 + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Hapalosiphon welwitschii A0A067YX61
-
-
Hapalosiphon welwitschii UTEX B 1830 A0A067YX61
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
12-epi-fischerindole U + 2-oxoglutarate + O2 + bromide pre-saturating the WelO5 active site with a non-native bromide anion is found to be critical to the highly selective in vitro transfer of bromine, instead of chlorine Hapalosiphon welwitschii 13R-bromo-12-epi-fischerindole U + succinate + CO2 + H2O
-
 ?
12-epi-fischerindole U + 2-oxoglutarate + O2 + bromide pre-saturating the WelO5 active site with a non-native bromide anion is found to be critical to the highly selective in vitro transfer of bromine, instead of chlorine Hapalosiphon welwitschii UTEX B 1830 13R-bromo-12-epi-fischerindole U + succinate + CO2 + H2O
-
 ?
12-epi-fischerindole U + 2-oxoglutarate + O2 + chloride
-
 Hapalosiphon welwitschii 12-epi-fischerindole G + succinate + CO2 + H2O
-
 ?
12-epi-fischerindole U + 2-oxoglutarate + O2 + chloride
-
 Hapalosiphon welwitschii UTEX B 1830 12-epi-fischerindole G + succinate + CO2 + H2O
-
 ?
12-epi-hapalindole C + 2-oxoglutarate + O2 + chloride
-
 Hapalosiphon welwitschii 12-epi-hapalindole E + succinate + CO2 + H2O
-
 ?
12-epi-hapalindole C + 2-oxoglutarate + O2 + chloride
-
 Hapalosiphon welwitschii UTEX B 1830 12-epi-hapalindole E + succinate + CO2 + H2O
-
 ?

Synonyms

Synonyms Comment Organism
welO5
-
 Hapalosiphon welwitschii

General Information

General Information Comment Organism
metabolism the enzyme is involved in welwitindolinone biosynthesis Hapalosiphon welwitschii