Literature summary for 1.14.20.1 extracted from
Cicero, G.; Carbonera, C.; Valegard, K.; Hajdu, J.; Andersson, I.; Ranghino, G.
Study of the oxidative half-reaction catalyzed by a non-heme ferrous catalytic center by means of structural and computational methodologies (2007), Int. J. Quantum Chem., 107, 1514-1522.
No PubMed abstract available
Crystallization (Commentary)
Crystallization (Comment) |
Organism |
quantum mechanical calculations of the first part of the reaction based on the high-resolution structures of the active site and its complexes with ligands |
Streptomyces clavuligerus |
Organism
Organism |
UniProt |
Comment |
Textmining |
Streptomyces clavuligerus |
P18548 |
- |
- |
Reaction
Reaction |
Comment |
Organism |
Reaction ID |
penicillin N + 2-oxoglutarate + O2 = deacetoxycephalosporin C + succinate + CO2 + H2O |
presence of a stable iron-peroxo intermediate in equilibrium with a more reactive ferryl species. Formation of CO2 as a leaving group by decarboxylation of 2-oxoglutarate. Substitution of CO2 by the penicillin substrate triggers the oxidation reaction in a booby-trap-like mechanism |
Streptomyces clavuligerus |
|