Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.20.1 extracted from

  • Cicero, G.; Carbonera, C.; Valegard, K.; Hajdu, J.; Andersson, I.; Ranghino, G.
    Study of the oxidative half-reaction catalyzed by a non-heme ferrous catalytic center by means of structural and computational methodologies (2007), Int. J. Quantum Chem., 107, 1514-1522.
No PubMed abstract available

Crystallization (Commentary)

Crystallization (Comment) Organism
quantum mechanical calculations of the first part of the reaction based on the high-resolution structures of the active site and its complexes with ligands Streptomyces clavuligerus

Organism

Organism UniProt Comment Textmining
Streptomyces clavuligerus P18548
-
-

Reaction

Reaction Comment Organism Reaction ID
penicillin N + 2-oxoglutarate + O2 = deacetoxycephalosporin C + succinate + CO2 + H2O presence of a stable iron-peroxo intermediate in equilibrium with a more reactive ferryl species. Formation of CO2 as a leaving group by decarboxylation of 2-oxoglutarate. Substitution of CO2 by the penicillin substrate triggers the oxidation reaction in a booby-trap-like mechanism Streptomyces clavuligerus