BRENDA - Enzyme Database show
show all sequences of 1.14.19.8

A gene cluster for biosynthesis of the sesquiterpenoid antibiotic pentalenolactone in Streptomyces avermitilis

Tetzlaff, C.N.; You, Z.; Cane, D.E.; Takamatsu, S.; Omura, S.; Ikeda, H.; Biochemistry 45, 6179-6186 (2006)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Streptomyces avermitilis
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+
-
718843
Streptomyces avermitilis
pentalenolactone + 2 oxidized ferredoxin + 2 H2O
-
-
-
ir
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+
-
718843
Streptomyces avermitilis
pentalenolactone + 2 oxidized ferredoxin + 2 H2O
-
-
-
ir
Other publictions for EC 1.14.19.8
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745166
Duan
The cytochrome P450-catalyzed ...
Streptomyces arenae
J. Am. Chem. Soc.
138
12678-12689
2016
-
-
1
1
8
-
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7
-
1
-
-
-
2
-
-
1
1
-
-
-
-
2
1
1
-
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7
1
-
-
2
-
-
-
-
-
1
2
1
8
-
-
-
-
7
-
1
-
-
-
-
-
1
-
-
-
-
2
1
1
-
-
7
1
-
-
-
-
2
2
-
7
7
727767
Zhu
Product-mediated regulation of ...
Streptomyces arenae, Streptomyces arenae TUE469, Streptomyces exfoliatus, Streptomyces exfoliatus UC5319
J. Bacteriol.
195
1255-1266
2013
-
-
-
-
-
-
-
-
-
-
-
4
-
9
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
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-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
719654
Zhu
Genome mining in Streptomyces. ...
Streptomyces arenae, Streptomyces arenae TUE469, Streptomyces exfoliatus, Streptomyces exfoliatus UC5319
J. Am. Chem. Soc.
133
2128-2131
2011
-
-
2
-
-
-
-
2
-
-
-
-
-
15
-
-
2
-
-
-
-
-
4
2
-
-
-
2
-
-
-
2
-
-
-
-
-
2
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
2
-
-
-
-
4
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
718843
Tetzlaff
A gene cluster for biosynthesi ...
Streptomyces avermitilis
Biochemistry
45
6179-6186
2006
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-
-
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-
-
-
-
-
-
-
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1
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1
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1
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