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Literature summary for 1.14.19.77 extracted from
- Orphan enzymes in ether lipid metabolism (2013), Biochimie, 95, 59-65.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | bound | Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 | Homo sapiens | i.e. plasmanylethanolamine | O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O | i.e. plasmenylethanolamine | ? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme converts plasmanylethanolamine into plasmenylethanolamine by introducing a vinyl double bound. It requires cytochrome b5, molecular oxygen and either NADPH or NADH as cofactors for functional catalysis. Plasmanylcholines are no substrates for plasmanylethanolamine desaturase | Homo sapiens | ? | - |
? | |
| O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 | i.e. plasmanylethanolamine | Homo sapiens | O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O | i.e. plasmenylethanolamine | ? | |
| O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + reduced cytochrome b5 + O2 | i.e. plasmanylethanolamine, the reaction involves reaction involving cytochrome b5 reductase, molecular oxygen and a reduction equivalent | Homo sapiens | O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized cytochrome b5 + 2 H2O | i.e. plasmenylethanolamine | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DELTA1'-alkyl desaturase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | plasmanylethanolamine desaturase is a key enzyme for the biosynthesis of one of the most abundant phospholipidsin the body, the plasmalogens. Ether lipid metabolism including biosynthesis and degradation of platelet-activating factor and plasmalogens, overview | Homo sapiens |
| additional information | the enzyme is a defined enzyme without assigned sequence, these kind of enzymes are known as orphan enzymes | Homo sapiens |
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Release 2023.1 (January 2023)
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