Literature summary for 1.14.19.70 extracted from

Kavanagh, M.E.; Gray, J.L.; Gilbert, S.H.; Coyne, A.G.; McLean, K.J.; Davis, H.J.; Munro, A.W.; Abell, C.
Substrate fragmentation for the design of M. tuberculosis CYP121 inhibitors (2016), ChemMedChem, 11, 1924-1935 .

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Application

Application	Comment	Organism
medicine	the CYP121 gene is essential for survival of Mycobacterium tuberculosis in vitro and the enzyme is believed to be the molecular target responsible for the anti-tubercular efficacy of azole antifungal compounds pharmacology	Mycobacterium tuberculosis

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	the cyclo-dipeptide substrates of the essential Mycobacterium tuberculosis enzyme CYP121 are deconstructed into their component fragments and screened against the enzyme	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WPP7	-	-

Synonyms

Synonyms	Comment	Organism
CYP121	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)