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Literature summary for 1.14.19.70 extracted from

  • Hudson, S.; McLean, K.; Surade, S.; Yang, Y.; Leys, D.; Ciulli, A.; Munro, A.; Abell, C.
    Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121 (2012), Angew. Chem. Int. Ed. Engl., 51, 9311-9316.
    View publication on PubMed
Search for more literature for 1.14.19.70

Inhibitors

Inhibitors Comment Organism Structure
2-methylquinolin-6-amine
-
 Mycobacterium tuberculosis
3-(1H-1,2,4-triazol-1-ylmethyl)aniline
-
 Mycobacterium tuberculosis
4,4'-(1H-1,2,3-triazole-1,4-diyl)diphenol
-
 Mycobacterium tuberculosis
4,4'-(1H-1,2,3-triazole-1,5-diyl)diphenol
-
 Mycobacterium tuberculosis
4-(1,3-thiazol-5-yl)quinolin-6-amine
-
 Mycobacterium tuberculosis
4-(1H-1,2,3-triazol-1-yl)quinolin-6-amine
-
 Mycobacterium tuberculosis
4-(1H-1,2,4-triazol-1-yl)phenol
-
 Mycobacterium tuberculosis
4-(1H-1,2,4-triazol-1-yl)quinolin-6-amine
-
 Mycobacterium tuberculosis
4-(1H-1,2,4-triazol-1-yl)quinoline
-
 Mycobacterium tuberculosis
4-(1H-imidazol-1-yl)quinolin-6-amine
-
 Mycobacterium tuberculosis
4-(1H-pyrazol-1-yl)quinolin-6-amine
-
 Mycobacterium tuberculosis
4-(4-phenoxy-1H-pyrazol-3-yl)benzene-1,3-diol
-
 Mycobacterium tuberculosis
4-(pyridin-3-yl)quinolin-6-amine
-
 Mycobacterium tuberculosis
4-oxo-4,5,6,7-tetrahydro-1-benzofuran-3-carboxylic acid
-
 Mycobacterium tuberculosis
4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]benzene-1,3-diol
-
 Mycobacterium tuberculosis
4-[4-(4-methoxyphenyl)-1H-pyrazol-3-yl]benzene-1,3-diol
-
 Mycobacterium tuberculosis
6-nitro-4-(1H-1,2,4-triazol-1-yl)quinoline
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 Mycobacterium tuberculosis
-
 mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 Mycobacterium tuberculosis H37Rv
-
 mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WPP7
-
-
Mycobacterium tuberculosis H37Rv P9WPP7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
-
 Mycobacterium tuberculosis mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
-
 Mycobacterium tuberculosis H37Rv mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP121
-
 Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
heme
-
 Mycobacterium tuberculosis