Literature summary for 1.14.19.69 extracted from

Zhao, B.; Waterman, M.R.; Isin, E.M.; Sundaramoorthy, M.; Podust, L.M.
Ligand-assisted inhibition in cytochrome P450 158A2 from Streptomyces coelicolor A3(2) (2006), Biochemistry, 45, 7493-7500.

Search for more literature for 1.14.19.69

Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with inhibitor 4-phenylimidazole, crystallization in presence of malonic acid. Diffraction to 1.5 A resolution. Presence of malonic acid affects binding behaviour and increases inhibitory potency up to 2fold. Two molecules of malonate are found above the single inhibitor molecule in the active site, linked between the BC loop and beta 1-4/beta6-1 strands via hydrogen bond interactions to stabilize the conformational changes of the BC loop and beta strands that take place upon inhibitor binding. 4-Phenylimidazole can launch an extensive hydrogen-bonding network in the region of the F/G helices which may stabilize the conformational changes	Streptomyces coelicolor

Crystallization (Comment)

Organism

in complex with inhibitor 4-phenylimidazole, crystallization in presence of malonic acid. Diffraction to 1.5 A resolution. Presence of malonic acid affects binding behaviour and increases inhibitory potency up to 2fold. Two molecules of malonate are found above the single inhibitor molecule in the active site, linked between the BC loop and beta 1-4/beta6-1 strands via hydrogen bond interactions to stabilize the conformational changes of the BC loop and beta strands that take place upon inhibitor binding. 4-Phenylimidazole can launch an extensive hydrogen-bonding network in the region of the F/G helices which may stabilize the conformational changes

Streptomyces coelicolor

Inhibitors

Inhibitors	Comment	Organism	Structure
4-phenylimidazole	crystallization data. Presence of malonic acid affects binding behaviour and increases inhibitory potency up to 2fold	Streptomyces coelicolor

Organism

Organism	UniProt	Comment	Textmining
Streptomyces coelicolor	-	isoform CYP158A2	-
Streptomyces coelicolor A3(2)	-	isoform CYP158A2	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)