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Literature summary for 1.14.19.31 extracted from

  • Tonon, T.; Sayanova, O.; Michaelson, L.V.; Qing, R.; Harvey, D.; Larson, T.R.; Li, Y.; Napier, J.A.; Graham, I.A.
    Fatty acid desaturases from the microalga Thalassiosira pseudonana (2005), FEBS J., 272, 3401-3412.
    View publication on PubMed
Search for more literature for 1.14.19.31

Cloned(Commentary)

Cloned (Comment) Organism
gene TpdesK, encoded on chromosome 5, the gene has a single intron, phylogenetic analysis and tree, recombinant expression in Saccharomyces cerevisiae strain W303A1 Thalassiosira pseudonana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
docosa-7,10,13,16,19-pentaenoic acid + 2 ferrocytochrome b5 + O2 + 2 H+ Thalassiosira pseudonana
-
 docosa-4,7,10,13,16,19-hexaenoic acid + 2 ferricytochrome b5 + 2 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Thalassiosira pseudonana
-
 gene TpdesK
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information the enzyme is expressed during the exponential phase of growth Thalassiosira pseudonana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
docosa-7,10,13,16,19-pentaenoic acid + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Thalassiosira pseudonana docosa-4,7,10,13,16,19-hexaenoic acid + 2 ferricytochrome b5 + 2 H2O
-
 ?

Synonyms

Synonyms Comment Organism
DELTA4-desaturase
-
 Thalassiosira pseudonana

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
 Thalassiosira pseudonana

General Information

General Information Comment Organism
evolution the enzyme belongs to the front-end desaturases, phylogenetic analysis and tree, overview. Introns appear to have evolved independently among Tpdes genes Thalassiosira pseudonana
metabolism the enzyme is involved in production of the health beneficial polyunsaturated fatty acid docosahexaenoic acid Thalassiosira pseudonana