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Literature summary for 1.14.19.3 extracted from

  • Watanabe, K.; Ohno, M.; Taguchi, M.; Kawamoto, S.; Ono, K.; Aki, T.
    Identification of amino acid residues that determine the substrate specificity of mammalian membrane-bound front-end fatty acid desaturases (2016), J. Lipid Res., 57, 89-99 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.19.3

Cloned(Commentary)

Cloned (Comment) Organism
expression in Saccharomyces cerevisiae Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
A361Q activity is significantly lower than that of wild-type enzyme Rattus norvegicus
DELTA238P/DELTA239L activity is significantly lower than that of wild-type enzyme Rattus norvegicus
DELTA238P/DELTA239L decreased or null DELTA6 desaturase activity Rattus norvegicus
F166V/V167L activity is significantly lower than that of wild-type enzyme Rattus norvegicus
F356V/S358T activity is significantly lower than that of wild-type enzyme Rattus norvegicus
H410Y/E413K activity is significantly lower than that of wild-type enzyme Rattus norvegicus
I192T activity is significantly lower than that of wild-type enzyme Rattus norvegicus
K234N/S235M/L236delta decreased or null DELTA6 desaturase activity Rattus norvegicus
K234N/S235M/L236DELTA/K444Q activity is significantly lower than that of wild-type enzyme Rattus norvegicus
K444Q decreased or null DELTA6 desaturase activity Rattus norvegicus
N156T/A305V/Y182F/K234N/S235M/E365K/F166V/L423F/L424A/I195L/W245V acquisition of DELTA5 desaturase activity without losing DELTA6 desaturase activity Rattus norvegicus
N156T/A305V/Y182F/K234N/S235M/E365K/F166V/L423F/L424A/L248V/F322L/L323F/I195L/W245V acquisition of DELTA5 desaturase activity without losing DELTA6 desaturase activity Rattus norvegicus
N156T/A305V/Y182F/K234N/S235M/E365K/F166V/L423F/L424A/L248V/F322L/L323F/I195L/W245V/L396Y/V344P acquisition of DELTA5 desaturase activity without losing DELTA6 desaturase activity Rattus norvegicus
N156T/A305V/Y182F/K234N/S235M/E365K/F166V/L423F/L424A/L248V/F322L/L323F/I195L/W245V/L396Y/Y257H acquisition of DELTA5 desaturase activity without losing DELTA6 desaturase activity Rattus norvegicus
N156T/A305V/Y182F/K234N/S235M/E365K/F166V/L423F/L424A/L248V/F322L/L323F/I195L/W245V/L396Y/Y257H/V344P/I284F acquisition of DELTA5 desaturase activity without losing DELTA6 desaturase activity Rattus norvegicus
N156T/A305V/Y182F/K234N/S235M/E365K/F166V/L423F/L424A/L248V/F322L/L323F/I195L/W245V/L396Y/Y257H/V344P/I284F/F370A/I326V acquisition of DELTA5 desaturase activity without losing DELTA6 desaturase activity Rattus norvegicus
N156T/A305V/Y182F/K234N/S235M/E365K/F166V/L423F/L424A/L248V/F322L/L323F/I195L/W245V/L396Y/Y257H/V344P/I284F/F370A/Y352N acquisition of DELTA5 desaturase activity without losing DELTA6 desaturase activity Rattus norvegicus
N156T/A305V/Y182F/K234N/S235M/E365K/F166V/L423F/L424A/L248V/F322L/L323F/I195L/W245V/L396Y/Y257H/V344P/I284F/F370A/Y352N/I326V/Y188F/K190T acquisition of DELTA5 desaturase activity without losing DELTA6 desaturase activity Rattus norvegicus
N156T/A305V/Y182F/K234N/S235M/E365K/F166V/L423F/L424A/L248V/F322L/L323F/I195L/W245V/L396Y/Y257H/V344P/I284F/F370A/Y352N/I326V/Y188F/K190T/H410Y acquisition of DELTA5 desaturase activity without losing DELTA6 desaturase activity Rattus norvegicus
N156T/A305V/Y182F/K234N/S235M/E365K/F166V/L423F/L424A/L248V/F322L/L323F/I195L/W245V/L396Y/Y257H/V344P/I284F/F370A/Y352N/I326V/Y188F/K190T/H410Y/E413K acquisition of DELTA5 desaturase activity without losing DELTA6 desaturase activity Rattus norvegicus
N156T/A305V/Y182F/K234N/S235M/E365K/F166V/L423F/L424A/L248V/F322L/L323F/I195L/W245V/L396Y/Y257H/V344P/I284F/Y352N/I326V/H410Y acquisition of DELTA5 desaturase activity without losing DELTA6 desaturase activity Rattus norvegicus
N156T/A305V/Y182F/K234N/S235M/E365K/F166V/L423F/L424A/L248V/F322L/L323F/W245V acquisition of DELTA5 desaturase activity without losing DELTA6 desaturase activity Rattus norvegicus
P246S/L247V/Y249L activity is significantly lower than that of wild-type enzyme Rattus norvegicus
Q415E/E416S activity is significantly lower than that of wild-type enzyme Rattus norvegicus
Q415E/E416S decreased or null DELTA6 desaturase activity Rattus norvegicus
R216M activity is significantly lower than that of wild-type enzyme Rattus norvegicus
R216M decreased or null DELTA6 desaturase activity Rattus norvegicus
S209P/N211S activity is significantly lower than that of wild-type enzyme Rattus norvegicus
S209P/N211S decreased or null DELTA6 desaturase activity Rattus norvegicus
Y352N/R353V activity is significantly lower than that of wild-type enzyme Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane bound Rattus norvegicus 16020
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q9Z122
-
-

Synonyms

Synonyms Comment Organism
DELTA6 desaturase
-
 Rattus norvegicus
FADS2
-
 Rattus norvegicus