Literature summary for 1.14.19.20 extracted from

Acimovic, J.; Korosec, T.; Seliskar, M.; Bjorkhem, I.; Monostory, K.; Szabo, P.; Pascussi, J.M.; Belic, A.; Urleb, U.; Kocjan, D.; Rozman, D.
Inhibition of human sterol DELTA7-reductase and other postlanosterol enzymes by LK-980, a novel inhibitor of cholesterol synthesis (2011), Drug Metab. Dispos., 39, 39-46.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-(4-phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol	average content of 7-dehydrocholesterol in human primary hepatocytes after 2-(4-phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol treatment is, 34.16 times higher than that in nontreated cells, indicating that DHCR7 is the major target (minor targets are human sterol DELTA14-reductase, sterol DELTA24-reductase, and sterol C5-desaturase). In vitro kinetic measurements show that the half-life of 2-(4-phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol is at least 4.3 h. 2-(4-phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol does not induce CYP3A4 mRNA nor enzyme activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	primary hepatocytes are used for analysis	Homo sapiens	-
liver	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Dhcr7	-	Homo sapiens
sterol DELTA7-reductase	-	Homo sapiens

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Release 2023.1 (January 2023)