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Literature summary for 1.14.19.17 extracted from

  • Zhu, Q.; Yang, J.; Zhu, R.; Jiang, X.; Li, W.; He, S.; Jin, J.
    Dihydroceramide-desaturase-1-mediated caspase 9 activation through ceramide plays a pivotal role in palmitic acid-induced HepG2 cell apoptosis (2016), Apoptosis, 21, 1033-1044 .
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information DES1 downregulation by specific siRNA Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
DES1
-
Homo sapiens
dihydroceramide desaturase 1
-
Homo sapiens
dihydroceramide-desaturase-1
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Homo sapiens

General Information

General Information Comment Organism
malfunction DES1 inhibition by specific siRNA causing DES1 activity decrease can ameliorate the increase in ceramide, enhance dihydroceramide elevation, and inhibit the palmitic acid-induced increases in caspase 9 activity and caspase 3 activity, palmitic acid-mediated apoptosis and cell growth inhibition are also attenuated by DES1 downregulation Homo sapiens
physiological function dihydroceramide-desaturase-1-mediated caspase 9 activation through ceramide plays a pivotal role in palmitic acid-induced HepG2 cell apoptosis. Enzyme dihydroceramide desaturase 1 (DES1) plays a key role in palmitic acid-mediated caspase 9 and caspase 3 activation. Palmitoleic acid, an omega-7 monounsaturated fatty acid, reverses palmitic acid-induced apoptosis through DES1 - ceramide - caspase 9 - caspase 3 signaling Homo sapiens