Protein Variants | Comment | Organism |
---|---|---|
additional information | DES1 downregulation by specific siRNA | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
DES1 | - |
Homo sapiens |
dihydroceramide desaturase 1 | - |
Homo sapiens |
dihydroceramide-desaturase-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | DES1 inhibition by specific siRNA causing DES1 activity decrease can ameliorate the increase in ceramide, enhance dihydroceramide elevation, and inhibit the palmitic acid-induced increases in caspase 9 activity and caspase 3 activity, palmitic acid-mediated apoptosis and cell growth inhibition are also attenuated by DES1 downregulation | Homo sapiens |
physiological function | dihydroceramide-desaturase-1-mediated caspase 9 activation through ceramide plays a pivotal role in palmitic acid-induced HepG2 cell apoptosis. Enzyme dihydroceramide desaturase 1 (DES1) plays a key role in palmitic acid-mediated caspase 9 and caspase 3 activation. Palmitoleic acid, an omega-7 monounsaturated fatty acid, reverses palmitic acid-induced apoptosis through DES1 - ceramide - caspase 9 - caspase 3 signaling | Homo sapiens |