Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-oxo-N-(4-hydroxyphenyl)retinamide | - |
Homo sapiens | |
fenretinide | i.e. N-(4-hydroxyphenyl)retinamide, a synthetic retinoid, leads to an increase in C16 and C18 dihydroceramide substrate accumulation. Fenretinide induces degradation of SCD1 in human Rretinal pigment epithelium cells | Homo sapiens | |
additional information | no inhibition of the enzyme by N-[4-methoxyphenyl]retinamide and by non-retinoid RBP4 ligand A1120, RBP4 is a serum retinol-binding protein. The presence of fenretinide or 4-oxo-N-(4-hydroxyphenyl)retinamide leads to 2.7 and 3fold increases in ratio for C16 and C18 ceramides ratio respectively | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00767 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ARPE-19 cell | retinal pigment epithelial cells | Homo sapiens | - |
retinal pigment epithelium cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
SCD1 | - |
Homo sapiens |
stearoyl-CoA desaturase 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | lipid and ceramide content analysis in untreated and inhibitor-treated ARPE-19 cells, overview | Homo sapiens |