Application | Comment | Organism |
---|---|---|
pharmacology | enhancing SCD1-mediated desaturation of saturated fatty acids and subsequent formation of neutral lipid droplets may become a promising therapeutic target to reduce saturated fatty acid-induced lipotoxicity in the pathogenesis of diabetic nephropathy | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | siRNA-mediated downregulation of stearoyl-coenzyme A desaturase-1 (SCD1) in diabetic proximal tubular epithelial cells | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ | Mus musculus | - |
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P13516 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
renal proximal tubule | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ | - |
Mus musculus | oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SCD1 | - |
Mus musculus |
stearoyl-CoA desaturase-1 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome b5 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | siRNA against SCD1 exacerbates the apoptosis | Mus musculus |
metabolism | the enzyme is involved in the metabolism of free fatty acids | Mus musculus |
additional information | stearoyl-CoA desaturase-1 (SCD1) expression level significantly decreases in the kidneys of high-fat diet (HFD)-induced diabetic mice, compared with non-diabetic mice | Mus musculus |
physiological function | stearoyl-CoA desaturase-1, SCD1, is an enzyme that desaturates satruated fatty acids (SFA), converting them to monounsaturated fatty acids (MUFAs), leading to the formation of neutral lipid droplets. SCD1 activity protects cells against lipotoxicity-mediated apoptosis in proximal tubular cells. In culture, retrovirus-mediated overexpression of SCD1 or MUFA treatment significantly ameliorates saturated fatty acid-induced apoptosis in proximal tubular epithelial cells by enhancing intracellular lipid droplet formation. Both overexpression of SCD1 and monounsaturated fatty acid treatment reduces SFA-induced apoptosis via reducing endoplasmic reticulum stress in cultured proximal tubular epithelial cells | Mus musculus |