Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.19.1 extracted from

  • Peter, A.; Weigert, C.; Staiger, H.; Rittig, K.; Cegan, A.; Lutz, P.; Machicao, F.; Haering, H.U.; Schleicher, E.
    Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity (2008), Am. J. Physiol. Endocrinol. Metab., 295, E339-E349.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
cis-10,trans-12-conjugated linoleic acid
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
arterial endothelial cell
-
Homo sapiens
-
coronary artery smooth muscle cell line
-
Homo sapiens
-
HAEC cell
-
Homo sapiens
-
HEK-293 cell
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-
myotube
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
SCD-1
-
Homo sapiens
stearoyl-CoA desaturase-1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens SCD-1 is not upregulated in HAEC cells upon palmitate treatment additional information
Homo sapiens SCD-1 expression is about 2fold upregulated in coronary artery smooth muscle cells, myotubes, and Hep-G2 cells at 0.5 mM palmitate, SCD-1 is upregulated using 0.01 mM TO-901317 in HAEC cells, inhibition of SCD-1 with cis-10,trans-12-conjugated linoleic acid blocks the upregulating effect of TO-901317 up