Literature summary for 1.14.19.1 extracted from

Stefan, N.; Peter, A.; Cegan, A.; Staiger, H.; Machann, J.; Schick, F.; Claussen, C.D.; Fritsche, A.; Haering, H.U.; Schleicher, E.
Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans (2008), Diabetologia, 51, 648-656.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
stearoyl-CoA + ferrocytochrome b5 + O2 + H+	Homo sapiens	rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, hepatic SCD1 activity may regulate fat accumulation in the liver and possibly protects from insulin resistance in obesity, overview	oleoyl-CoA + ferricytochrome b5 + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	hepatic SCD1 activity index correlates negatively with liver fat and positively with insulin sensitivity, overview	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
stearoyl-CoA + ferrocytochrome b5 + O2 + H+	-	Homo sapiens	oleoyl-CoA + ferricytochrome b5 + H2O	-	?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+	rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, hepatic SCD1 activity may regulate fat accumulation in the liver and possibly protects from insulin resistance in obesity, overview	Homo sapiens	oleoyl-CoA + ferricytochrome b5 + H2O	-	?

Synonyms

Synonyms	Comment	Organism
SCD1	-	Homo sapiens
stearoyl-CoA desaturase 1	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ferrocytochrome b5	-	Homo sapiens

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Release 2023.1 (January 2023)