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Literature summary for 1.14.19.1 extracted from

  • Gutierrez-Juarez, R.; Pocai, A.; Mulas, C.; Ono, H.; Bhanot, S.; Monia, B.P.; Rossetti, L.
    Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance (2006), J. Clin. Invest., 116, 1686-1695.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.19.1

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6J mice
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Mus musculus C57/BL6J
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 C57BL/6J mice
-
Rattus norvegicus
-
 Spraque-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
liver mRNA decreased by 80% following 2 injections of Scd1 sequence-specific antisense oligodeoxynucleotide over 5 days, real-time PCR Rattus norvegicus
-
liver treatment with Scd1 sequence-specific antisense oligodeoxynucleotide decreases mRNA and protein, real-time PCR Mus musculus
-
additional information decreased mRNA levels in epididymal fat pads after 2 injections of Scd1 sequence-specific antisense oligodeoxynucleotide over 5 days Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 enzyme activity decreases by 50% in the liver after treatment with Scd1 sequence-specific antisense oligodeoxynucleotide compared with animals treated with scrambled antisense oligodeoxynucleotide Rattus norvegicus
additional information
-
 enzyme activity increased by HF feeding and decreased after treatment with Scd1 sequence-specific antisense oligodeoxynucleotide compared with animals treated with scrambled antisense oligodeoxynucleotide Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
stearoyl-CoA + AH2 + O2
-
 Mus musculus oleoyl-CoA + A + H2O
-
 ?
stearoyl-CoA + AH2 + O2
-
 Rattus norvegicus oleoyl-CoA + A + H2O
-
 ?
stearoyl-CoA + AH2 + O2
-
 Mus musculus C57/BL6J oleoyl-CoA + A + H2O
-
 ?

Synonyms

Synonyms Comment Organism
SCD1
-
 Rattus norvegicus