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Literature summary for 1.14.19.1 extracted from
- Stearoyl-CoA desaturase: a new therapeutic target of liver steatosis (2006), Drug Develop. Res., 67, 643-650.
No PubMed abstract available
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression in CHO cells results in a significant increase in the rate of triglyceride synthesis | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | leptin-deficient obese ob/ob mice lacking SCD1 showed markedly reduced adiposity, despite higher food intake | Mus musculus |
| additional information | mice with targeted disruption in the SCD1 gene have increased energy expenditure, reduced body adiposity, increased insulin sensitivity and are resistant to diet-induced obesity | Mus musculus |
| additional information | SCD1 -/- mice have a decrease in cellular levels of malonyl-CoA in the liver | Mus musculus |
| additional information | SCD1 deficiency attenuates fasting-induced liver steatosis in peroxisome proliferator-activated receptor alpha-deficient mice | Mus musculus |
| additional information | SCD1 deficiency corrects the hypometabolic phenotype and hepatic steatosis of ob/ob mice | Mus musculus |
| additional information | SCD1 deficiency increases the rate of beta-oxidation in liver, skeletal muscle and brown adipose tissue | Mus musculus |
| additional information | SCD1-deficient mice show significantly higher total and resting oxygen consumption than littermate controls | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | inhibition of SCD1 leads to reduction in lipid accumulation | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P13011 | - |
- |
| Mus musculus | P13516 | - |
- |
| Mus musculus | Q6T707 | - |
- |
| Mus musculus | Q99PL7 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | SCD1 isoform | Mus musculus | - |
| harderian gland | SCD3 isoform | Mus musculus | - |
| heart | SCD4 isoform | Mus musculus | - |
| liver | SCD1 isoform | Mus musculus | - |
| liver | SCD2 isoform only in early stages | Mus musculus | - |
| additional information | SCD2 isoform is ubiquitously expressed in most tissues except liver | Mus musculus | - |
| preputial gland | SCD3 isoform | Mus musculus | - |
| skin | sebocytes, SCD3 isoform | Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
fasting reduces hepatic SCD1 protein expression and activity, and refeeding a high-carbohydrate or a high-sucrose diet increases both | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SCD1 | - |
Mus musculus |
| SCD2 | - |
Mus musculus |
| SCD3 | - |
Mus musculus |
| SCD4 | - |
Mus musculus |
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Release 2023.1 (January 2023)
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