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Literature summary for 1.14.19.1 extracted from

  • McDonald, T.M.; Kinsella, J.E.
    Stearyl-CoA desaturase of bovine mammary microsomes (1973), Arch. Biochem. Biophys., 156, 223-231.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,2 diglycerides only slight depression Bos taurus
EDTA more than 95% inhibition Bos taurus
ethanol depression Bos taurus
lysophosphatidylcholine
-
Bos taurus
oleoyl-CoA depression Bos taurus
palmitoyl-CoA depression Bos taurus
stearoyl-CoA substrate inhibition above 0.05 mM Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
NADH
-
Bos taurus
0.025
-
stearoyl-CoA
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome membrane bound Bos taurus
-
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
cow
-

Source Tissue

Source Tissue Comment Organism Textmining
mammary gland lactating Bos taurus
-
additional information no activity in liver and perirenal adipose microsomes Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0004
-
-
Bos taurus

Storage Stability

Storage Stability Organism
-30°C, freeze-dried microsomal preparation, 12 months stable, activity is retained Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + NAD(P)H + O2
-
Bos taurus palmitoleate + NAD(P)+ + H2O
-
?
stearoyl-CoA + NADH + O2
-
Bos taurus oleoyl-CoA + NAD+ + H2O
-
?
stearoyl-CoA + NADPH + O2
-
Bos taurus oleoyl-CoA + NADP+ + H2O
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Bos taurus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
8 50 rate of desaturation of stearoyl-CoA increases Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
range from pH 6.5 to 7.5 Bos taurus
7.4
-
assay at Bos taurus

pH Range

pH Minimum pH Maximum Comment Organism
5.5 9 pH 5.5: about 80% of maximum activity, pH 9.0: about 45% of maximum activity Bos taurus

Cofactor

Cofactor Comment Organism Structure
NAD+ supports desaturation Bos taurus
NADH preferred electron donor Bos taurus
NADP+ supports desaturation Bos taurus
NADPH
-
Bos taurus