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Literature summary for 1.14.18.6 extracted from

  • Herzfeld, E.; Speh, L.; Strauss, C.; Scheller, C.
    Nimodipine but not nifedipine promotes expression of fatty acid 2-hydroxylase in a surgical stress model based on neuro2a cells (2017), Int. J. Mol. Sci., 18, E964 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus Q5MPP0
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Source Tissue

Source Tissue Comment Organism Textmining
Neuro-2a cell
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 Mus musculus
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Synonyms

Synonyms Comment Organism
FA2H
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 Mus musculus
fatty acid 2-hydroxylase
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus fatty acid 2-hydroxylase (FA2H) is upregulated in vitro by nimodipine, a component of myelin synthesis. Nimodipine but not nifedipine increases FA2H protein levels and also significantly increases mRNA levels of FA2H in both undifferentiated and differentiated Neuro2a cells. Osmotic (NaCl) stress increases FA2H mRNA expression, synergistically with nifedipine-induced stress, overview up

General Information

General Information Comment Organism
physiological function undifferentiated and differentiated Neuro2a cells are protected from mechanical, heat (42°C) and oxidative stress by nimodipine, or at least to a lower extent by nifedipine. Higher expression of enzyme FA2H induced by nimodipine may cause higher survival of Neuro2a cells stressed with surgery-like stressors Mus musculus