Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
RT4-D6P2T cell | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
FA2H | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | treatment of D6P2T Schwannoma cells with dibutyryl-cAMP induces exit from the cell cycle with concomitant upregulation of FA2H | up |
General Information | Comment | Organism |
---|---|---|
physiological function | partial silencing of fatty acid 2-hydroxylase FA2H in D6P2T cells results in 60-70% reduction of hydroxyl fatty acid-dihydroceramide and hydroxyl fatty acid-ceramide, with no effect on nonhydroxy dihydroceramide and ceramide.Under these conditions, dibutyryl-cAMP no longer induces cell cycle exit, and cells continue to grow and divide. FA2H silencing prevents dibutyryl-cAMP-induced upregulation of cyclin-dependent kinase inhibitors p21 and p27 | Rattus norvegicus |