Literature summary for 1.14.18.6 extracted from

Alderson, N.; Rembiesa, B.; Walla, M.; Bielawska, A.; Bielawski, J.; Hama, H.
The human FA2H gene encodes a fatty acid 2-hydroxylase (2004), J. Biol. Chem., 279, 48562-48568.

Search for more literature for 1.14.18.6

Protein Variants

Protein Variants	Comment	Organism
additional information	FA2H lacking the N-terminal cytochrome b5 domain has little activity	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	protein contains four potential transmembrane domains	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q7L5A8	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-
colon	-	Homo sapiens	-

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome b5	FA2H protein contains an N-terminal cytochrome b5 domain	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	COS7 cells expressing human FA2H contain 3-20fold higher levels of 2-hydroxyceramides (C16, C18, C24, and C24:1) and 2-hydroxy fatty acids compared with control cells	Homo sapiens

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Release 2023.1 (January 2023)