Literature summary for 1.14.18.2 extracted from

Bighignoli, B.; Niini, T.; Grahn, R.A.; Pedersen, N.C.; Millon, L.V.; Polli, M.; Longeri, M.; Lyons, L.A.
Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domestic cat AB blood group (2007), BMC Genet., 8, 27.

Search for more literature for 1.14.18.2

Cloned(Commentary)

Cloned (Comment)	Organism
DNA and amino acid sequence determination of wild-type and mutant alleles, genotyping and expression analysis, overview	Felis catus

Protein Variants

Protein Variants	Comment	Organism
G1266A	naturally occuring silent mtation	Felis catus
G139A	naturally occuring missense mutation	Felis catus
G1600A	naturally occuring silent mtation	Felis catus
additional information	mutations in type B cats likely disrupt the gene function of CMAH, leading to a predominance of NeuAc in blood types, genotyping, overview	Felis catus
T265A	naturally occuring missense mutation	Felis catus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe2+	in cofactor ferrocytochrome b5	Felis catus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CMP-N-acetylneuraminate + ferrocytochrome b5 + O2 + H+	Felis catus	the enzyme determines the sugar bound to the red cell by converting NeuAc to NeuGc. Thus, mutations in CMAH may cause the A and B blood types, two major serotypes. Blood type A is dominant to type B. A rare type AB may also be allelic and is suspected to be recessive to A and dominant to B. Cat blood type antigens are defined: N-glycolylneuraminic acid, NeuGc, is associated with type A and N-acetylneuraminic acid, NeuAc, with type B, overview	CMP-N-glycoloylneuraminate + ferricytochrome b5 + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Felis catus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CMP-N-acetylneuraminate + ferrocytochrome b5 + O2 + H+	-	Felis catus	CMP-N-glycoloylneuraminate + ferricytochrome b5 + H2O	-	?
CMP-N-acetylneuraminate + ferrocytochrome b5 + O2 + H+	the enzyme determines the sugar bound to the red cell by converting NeuAc to NeuGc. Thus, mutations in CMAH may cause the A and B blood types, two major serotypes. Blood type A is dominant to type B. A rare type AB may also be allelic and is suspected to be recessive to A and dominant to B. Cat blood type antigens are defined: N-glycolylneuraminic acid, NeuGc, is associated with type A and N-acetylneuraminic acid, NeuAc, with type B, overview	Felis catus	CMP-N-glycoloylneuraminate + ferricytochrome b5 + H2O	-	?

Synonyms

Synonyms	Comment	Organism
CMAH	-	Felis catus
cytidine monophospho-N-acetylneuraminic acid hydroxylase	-	Felis catus

Cofactor

Cofactor	Comment	Organism	Structure
ferrocytochrome b5	-	Felis catus

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Release 2023.1 (January 2023)