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Literature summary for 1.14.18.2 extracted from

  • Gollub, M.; Schauer, R.; Shaw, L.
    Cytidine monophosphate-N-acetylneuraminate hydroxylase in the starfish Asterias rubens and other echinoderms (1998), Comp. Biochem. Physiol. B, 120, 605-615.
    View publication on PubMed
Search for more literature for 1.14.18.2

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline 2 mM, 88% inhibition Asterias rubens
2,2'-dipyridyl 2 mM, 27% inhibition Asterias rubens
ferrozine 2 mM, 83% inhibition Asterias rubens
KCN 2 mM, 80% inhibition Asterias rubens
NaCl above 100 mM Asterias rubens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0029
-
 ferrocytochrome b5 pH 6.4, 25°C, amphiphilic form of ferrocytochrome b5 Asterias rubens
0.0032
-
 ferrocytochrome b5 pH 6.4, 25°C, soluble form of ferrocytochrome b5 Asterias rubens
0.0072
-
 CMP-N-acetylneuraminate pH 6.4, 25°C Asterias rubens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane bound to Asterias rubens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
FeSO4 activates Asterias rubens
NaCl maximal 3.5fold stimulation at 100 mM Asterias rubens
NaCl 100 mM activates Ctenodiscus crispatus
NaCl 100 mM activates Strongylocentrotus pallidus
NaCl 100 mM activates Muelleria sp.

Organism

Organism UniProt Comment Textmining
Asterias rubens
-
-
-
Ctenodiscus crispatus
-
-
-
Muelleria sp.
-
-
-
Strongylocentrotus pallidus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gonad
-
 Asterias rubens
-
gonad
-
 Ctenodiscus crispatus
-
gonad
-
 Strongylocentrotus pallidus
-
gonad
-
 Muelleria sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + ferrocytochrome b5 + O2
-
 Asterias rubens CMP-N-glycoloylneuraminate + ferricytrochrome b5 + H2O
-
 ?
CMP-N-acetylneuraminate + NADH + O2
-
 Asterias rubens CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22 27
-
 Asterias rubens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 6.6
-
 Asterias rubens

Cofactor

Cofactor Comment Organism Structure
ferrocytochrome b5
-
 Asterias rubens
NADH
-
 Asterias rubens