BRENDA - Enzyme Database show
show all sequences of 1.14.18.2

Distribution and localization of CMP-N-acetylneuraminic acid hydroxylase and N-glycolylneuraminic acid-containing glycoconjugates in porcine lymph node and peripheral blood lymphocytes

Malykh, Y.N.; Krisch, B.; Shaw, L.; Warner, T.G.; Sinicrop, D.; Smith, R.; Chang, J.; Schauer, R.; Eur. J. Cell Biol. 80, 48-58 (2001)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
in the vicinity of the nuclear membrane and the outer membrane of the mitochondria
Sus scrofa
5829
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Sus scrofa
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
lymph node
-
Sus scrofa
-
lymphocyte
from thymus, spleen, lymph node and peripheral blood. Highest activity in peripheral blood lymphocytes
Sus scrofa
-
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
in the vicinity of the nuclear membrane and the outer membrane of the mitochondria
Sus scrofa
5829
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
lymph node
-
Sus scrofa
-
lymphocyte
from thymus, spleen, lymph node and peripheral blood. Highest activity in peripheral blood lymphocytes
Sus scrofa
-
Other publictions for EC 1.14.18.2
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745641
Gao
Production of alpha1,3-galact ...
Sus scrofa
J. Reprod. Dev.
63
17-26
2017
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1
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1
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2
2
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746206
Gandolfi
A novel variant in CMAH is as ...
Felis catus
PLoS ONE
11
e0154973
2016
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1
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3
3
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746215
Omi
Molecular characterization of ...
Felis catus
PLoS ONE
11
e0165000
2016
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1
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8
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1
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2
2
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746539
Sakai
Knockout of cytidine monophos ...
Sus scrofa
Transplant. Proc.
48
1320-1322
2016
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1
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1
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744458
Takahashi
Production and purification o ...
Chlorocebus aethiops, no activity in Homo sapiens
Biol. Pharm. Bull.
38
1220-1226
2015
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1
1
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3
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1
1
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1
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2
2
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727918
Bergfeld
Metabolism of vertebrate amino ...
Mus musculus
J. Biol. Chem.
287
28865-28881
2012
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4
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728834
Ikeda
A cloning of cytidine monophos ...
Sus scrofa
Transplant. Proc.
44
1136-1138
2012
-
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1
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6
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711964
Kavaler
Pancreatic {beta}-cell failure ...
Mus musculus
FASEB J.
25
1887-1893
2011
-
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5
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1
1
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701238
Nystedt
Human CMP-N-acetylneuraminic a ...
Homo sapiens
Stem Cells
28
258-267
2010
-
1
1
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1
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1
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1
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8
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8
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1
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711142
Song
Cloning and functional charact ...
Sus scrofa
Biochem. J.
427
179-188
2010
-
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1
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3
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6
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6
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1
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1
1
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712638
Tahara
Immunological property of anti ...
Mus musculus
J. Immunol.
184
3269-3275
2010
-
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1
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1
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697129
Schauer
Low incidence of N-glycolylneu ...
no activity in Gallus gallus, no activity in Ornithorhynchus anatinus, no activity in Taeniopygia guttata
Carbohydr. Res.
344
1494-1500
2009
-
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13
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685822
Bighignoli
Cytidine monophospho-N-acetyln ...
Felis catus
BMC Genet.
8
27
2007
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1
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5
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1
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1
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4
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673862
Hayakawa
Fixation of the human-specific ...
no activity in Homo sapiens
Genetics
172
1139-1146
2006
-
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639332
Gollub
Isolation and characterization ...
Asterias rubens
Comp. Biochem. Physiol. B
134
89-101
2003
-
-
-
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-
1
3
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1
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5
-
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1
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1
1
2
2
1
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2
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2
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2
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1
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3
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1
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1
1
2
2
1
-
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2
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658179
Chenu
Reduction of CMP-N-acetylneura ...
Cricetulus griseus
Biochim. Biophys. Acta
1622
133-144
2003
-
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5
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2
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2
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639323
Chou
Inactivation of CMP-N-acetylne ...
no activity in Homo sapiens
Proc. Natl. Acad. Sci. USA
99
11736-11741
2002
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5
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1
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639336
Malykh
-
Regulation of N-glycolylneuram ...
Sus scrofa
Biochem. J.
22
2-29
2002
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639320
Martensen
Cloning and expression of a me ...
Asterias rubens
Eur. J. Biochem.
268
5157-5166
2001
-
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1
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1
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1
-
7
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1
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1
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1
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1
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639330
Malykh
Distribution and localization ...
Sus scrofa
Eur. J. Cell Biol.
80
48-58
2001
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1
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672435
Malykh
N-Glycolylneuraminic acid in h ...
Homo sapiens
Biochimie
83
623-634
2001
-
1
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3
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1
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639324
Irie
CMP-N-acetylneuraminic acid hy ...
Mus musculus, no activity in Homo sapiens
Biochem. Biophys. Res. Commun.
248
330-333
1998
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1
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1
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4
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639329
Malykh
The role of CMP-N-acetylneuram ...
Sus scrofa
Glycoconjugate J.
15
885-893
1998
-
-
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1
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2
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9
-
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2
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1
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1
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1
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9
-
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2
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-
639331
Gollub
Cytidine monophosphate-N-acety ...
Asterias rubens, Ctenodiscus crispatus, Muelleria sp., Strongylocentrotus pallidus
Comp. Biochem. Physiol. B
120
605-615
1998
-
-
-
-
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5
3
1
5
-
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4
-
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4
-
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2
-
1
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1
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2
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2
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5
-
3
1
5
-
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4
-
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2
-
1
-
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-
1
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-
639318
Schlenzka
CMP-N-acetylneuraminic acid hy ...
Sus scrofa
FEBS Lett.
385
197-200
1996
-
-
1
-
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2
1
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2
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1
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1
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2
1
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1
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-
639328
Koyama
A naturally occurring 46-amino ...
Mus musculus
Glycoconjugate J.
13
353-358
1996
-
-
1
-
1
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2
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1
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3
-
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1
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1
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1
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1
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2
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1
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1
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1
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639322
Kawano
Molecular cloning of cytidine ...
Mus musculus
J. Biol. Chem.
270
16458-16463
1995
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4
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639319
Shaw
CMP-N-acetylneuraminic acid hy ...
Bos taurus, Mus musculus, Sus scrofa
Eur. J. Biochem.
219
1001-1011
1994
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639321
Kawano
Biosynthesis of N-glycolylneur ...
Mus musculus
J. Biol. Chem.
269
9024-9029
1994
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639326
Takematsu
Reaction mechanism underlying ...
Mus musculus
J. Biochem.
115
381-386
1994
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639327
Schneckenburger
Purification, characterization ...
Mus musculus
Glycoconjugate J.
11
194-203
1994
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639333
Schlenzka
Purification and characterizat ...
Sus scrofa
Glycobiology
4
675-683
1994
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639325
Schlenzka
Catalytic properties of the CM ...
Asterias rubens
Biochim. Biophys. Acta
1161
131-138
1993
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639317
Bergwerff
Nature and biosynthesis of sia ...
Asterias rubens
Biochimie
74
25-37
1992
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639334
Shaw
Mouse liver cytidine-5-monopho ...
Mus musculus
Eur. J. Biochem.
206
269-277
1992
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586940
Lepers
A study on the regulation of N ...
Mus musculus, Rattus norvegicus
Eur. J. Biochem.
193
715-723
1990
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639315
Kozutsumi
Participation of cytochrome b5 ...
Mus musculus
J. Biochem.
108
704-706
1990
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639314
Shaw
Detection of CMP-N-acetylneura ...
Mus musculus
Biochem. J.
263
355-363
1989
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639316
Muchmore
Biosynthesis of N-glycolyneura ...
Bos taurus, Mus musculus, Rattus norvegicus, Sus scrofa
J. Biol. Chem.
264
20216-20223
1989
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-
2
5
2
2
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4
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639313
Shaw
The biosynthesis of N-glycoloy ...
Sus scrofa
Biol. Chem. Hoppe-Seyler
369
477-486
1988
-
-
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-
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