Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(chloromethyl)-10-(2-fluorophenyl)-7,7-dimethyl-6,7,8,10-tetrahydropyrano[3,2-b]chromene-4,9-dione | - |
Agaricus bisporus | |
2-(chloromethyl)-10-(4-fluorophenyl)-7,7-dimethyl-6,7,8,10-tetrahydropyrano[3,2-b]chromene-4,9-dione | i.e. DHPC04, binding mode of R-DHPC04 and S-DHPC04 on the catalytic site of the enzyme, interactions between DHPC04 and residues His243 and Asn260 | Agaricus bisporus | |
2-(hydroxymethyl)-7,7-dimethyl-10-phenyl-6,7,8,10-tetrahydropyrano[3,2-b]chromene-4,9-dione | weak inhibition | Agaricus bisporus | |
4-(2-(hydroxymethyl)-7,7-dimethyl-4,9-dioxo-4,6,7,8,9,10-hexahydropyrano[3,2-b]chromen-10-yl)benzonitrile | - |
Agaricus bisporus | |
kojic acid | binding mode on the catalytic site of the enzyme | Agaricus bisporus | |
additional information | inhibition of tyrosinase by 4H-chromene analogues, synthesis, kinetic studies, and computational analysis, overview. Dihydropyrano[3,2-b] chromenediones (DHPCs), which are considered 4H-chromenes, are an important class of fused oxygenated heterocycles that are synthesized via a one-pot three-component reaction of kojic acid, an aldehyde and a 1,3-dione. Molecular docking and molecular modeling using the enzyme crystal structure, PDB ID 2Y9X, as template | Agaricus bisporus | |
tropolone | - |
Agaricus bisporus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | a binuclear copper enzyme. In the catalytic site of TYR, the bivalent copper ions are chelated by three individual histidine residues, overview | Agaricus bisporus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
128000 | - |
- |
Agaricus bisporus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-dopa + O2 | Agaricus bisporus | - |
2 dopaquinone + 2 H2O | - |
? | |
additional information | Agaricus bisporus | the enzyme catalyzes the oxidation of both monophenols (cresolase or monophenolase activity) and o-diphenols (catecholase or diphenolase activity) into reactive o-quinones | ? | - |
? | |
tyrosine + O2 | Agaricus bisporus | - |
dopaquinone + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Agaricus bisporus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-dopa + O2 | - |
Agaricus bisporus | 2 dopaquinone + 2 H2O | - |
? | |
additional information | the enzyme catalyzes the oxidation of both monophenols (cresolase or monophenolase activity) and o-diphenols (catecholase or diphenolase activity) into reactive o-quinones | Agaricus bisporus | ? | - |
? | |
tyrosine + O2 | - |
Agaricus bisporus | dopaquinone + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AbTYR | - |
Agaricus bisporus |
mushroom tyrosinase | - |
Agaricus bisporus |
tyr | - |
Agaricus bisporus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Agaricus bisporus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics | Agaricus bisporus | |
0.005 | - |
kojic acid | pH 7.2, temperature not specified in the publication | Agaricus bisporus | |
0.006 | - |
4-(2-(hydroxymethyl)-7,7-dimethyl-4,9-dioxo-4,6,7,8,9,10-hexahydropyrano[3,2-b]chromen-10-yl)benzonitrile | pH 7.2, temperature not specified in the publication | Agaricus bisporus | |
0.009 | - |
2-(chloromethyl)-10-(2-fluorophenyl)-7,7-dimethyl-6,7,8,10-tetrahydropyrano[3,2-b]chromene-4,9-dione | pH 7.2, temperature not specified in the publication | Agaricus bisporus | |
0.8 | - |
tropolone | pH 7.2, temperature not specified in the publication | Agaricus bisporus | |
2.4 | - |
2-(hydroxymethyl)-7,7-dimethyl-10-phenyl-6,7,8,10-tetrahydropyrano[3,2-b]chromene-4,9-dione | pH 7.2, temperature not specified in the publication | Agaricus bisporus |
General Information | Comment | Organism |
---|---|---|
metabolism | tyrosinase is a rate-limiting enzyme for controlling the production of melanin. The melanogenesis begins with the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by tyrosinase (TYR). The regulation of the TYR activity is directly connected with melanin biosynthesis | Agaricus bisporus |